CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1058
Family Name Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) Benzimidazole-4-carboxamide Family
No. of Seeds 9 No. of Other Members 93
Family Centroid CFAMM00226283 Functional Category Investigative Drug with Natural Product
Superfamily Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) Benzimidazole-4-carboxamide Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Histamine H1 receptor Ligand Astemizole Family 7 240
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
CC-486 family 7 103
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-7-[1H-b... 3 6
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Mitogen-activated protein kinase 14 inhibitor DEL-B, 14b family 2 0
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Gastrin/cholecystokinin type B receptor ligand 3-[[5-[2-(1-ada... 9 15
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07C6E6 family 3 16
Glycogen synthase kinase-3 beta inhibitor N-[3-(4,5-dichloroim... 2 1
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 1 6
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Coagulation factor X inhibitor AGN-PC-07C10A family 3 2
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-074DFG f... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Histamine H1 receptor and Substance-P receptor ligand AGN-PC-0... 10 6
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Smoothened homolog and Sonic hedgehog protein inhibitor 496794... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(1,2-oxazol-5-yl... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Smoothened homolog inhibitor N-[amino-[3-(1H-indol-2-yl)anilin... 1 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1
TGF-beta receptor type-1 ligand AGN-PC-07CRDB family 5 4
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00226326 CHEMBL336070 Bioactive 2-(3-hydroxyphenyl)-1H-benzimidazole-4-carboxamide
CFAMM00226361 CHEMBL338923 Bioactive 2-(3-hydroxy-4-methoxyphenyl)-1H-benzimidazole-4-carboxamide
CFAMM00226295 CHEMBL134116 Bioactive 2-(4-methoxy-3-prop-2-enoxyphenyl)-1H-benzimidazole-4-carboxamide
CFAMM00226323 CHEMBL83971 Bioactive AGN-PC-076ILV
CFAMM00226364 CHEMBL131820 Bioactive SureCN7319077
CFAMM00226385 CHEMBL133343 Bioactive 2-(3,4-dimethoxyphenyl)-1H-benzimidazole-4-carboxamide
CFAMM00226404 CHEMBL131719 Bioactive 188106-83-4
CFAMM00226272 CHEMBL337386 Bioactive 2-(1,3-benzodioxol-5-yl)-1H-benzimidazole-4-carboxamide
CFAMM00226283 DNC003467 Investigative Drug 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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