CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1087
Family Name Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimethoxyphenyl)-9h-purine-2,6-diamine Family
No. of Seeds 8 No. of Other Members 15
Family Centroid CFAMM00227272 Functional Category Investigative Drug
Superfamily Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimethoxyphenyl)-9h-purine-2,6-diamine Superfamily
Class Class 1967

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 1 0
Bombesin receptor subtype-3 ligand AGN-PC-077RXY family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00227280 DNC003541 Investigative Drug 8-(3,5-dimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227272 DNC003518 Investigative Drug 8-(2,3,4-trimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227286 DNC011412 Investigative Drug 8-(3,4,5-trimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227285 DNC011413 Investigative Drug 8-(2,5-dimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227278 DNC011392 Investigative Drug 8-(2,4,5-trimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227269 DNC011422 Investigative Drug 8-(2,4,6-trimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227275 DNC003529 Investigative Drug 8-(2,4-dimethoxyphenyl)-9H-purine-2,6-diamine
CFAMM00227282 DNC003522 Investigative Drug 8-(3,4-dimethoxyphenyl)-9H-purine-2,6-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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