CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1095
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-benzyl-piperazin-1-yl)-7-bromo-1h-indole Family
No. of Seeds 3 No. of Other Members 15
Family Centroid CFAMM00227356 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 2
Class Class 1973

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Transient receptor potential cation channel subfamily V member... 15 158
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Mast/stem cell growth factor receptor Kit Ligand 9-bromo-5,11-... 1 0
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histone deacetylase Inhibitor ST-5732 Family 8 6
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
5-hydroxytryptamine receptor 7 ligand 6-bromo-1-[2-[4-(cyclopr... 2 4
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPN family 4 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6080935 f... 1 0
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
Putative NP ZINC20763633 Family 16 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00227362 CHEMBL396540 Bioactive 4-(5-bromo-1H-indol-3-yl)-N,N-dimethylcyclohex-3-en-1-amine
CFAMM00227358 DNC011047 Investigative Drug (R,S)-1-(5-bromo-1H-indol-1-yl)propan-2-amine
CFAMM00227356 DNC003539 Investigative Drug 4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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