CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1096
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-benzyl-piperazin-1-yl)-5-chloro-1h-indole Family
No. of Seeds 6 No. of Other Members 48
Family Centroid CFAMM00227426 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 3
Class Class 1116

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 15 158
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Transient receptor potential cation channel subfamily V member... 15 457
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Amg 423 family 7 47
ABC294640 family 5 75
E7820 family 9 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Indisu... 2 14
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Transient receptor potential cation channel subfamily V member... 3 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Neuropeptide Y receptor type 5 ligand 2-(6-chloroindol-1-yl)-N... 4 23
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Glucocorticoid receptor and Progesterone receptor ligand [(3R,... 6 2
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
5-hydroxytryptamine receptor 6 ligand SureCN3147604 family 7 6
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Hepatocyte growth factor receptor ligand AGN-PC-09M1N4 family 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 14 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 11 2
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 2
Transient receptor potential cation channel subfamily V member... 2 0
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0
Prostaglandin D2 receptor 2 ligand AGN-PC-00QBAU family 1 24
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Nociceptin receptor ligand AGN-PC-07C3R0 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00227377 CHEMBL201454 Bioactive (2S)-1-(5-chloropyrrolo[2,3-f]quinolin-1-yl)propan-2-amine
CFAMM00227374 CHEMBL132446 Bioactive 5-chloro-3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indole
CFAMM00227426 DNC003543 Investigative Drug 4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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