CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1097
Family Name Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly-asp-amp26-] Family
No. of Seeds 5 No. of Other Members 38
Family Centroid CFAMM00227466 Functional Category Investigative Drug
Superfamily Integrin alpha-V and Integrin beta-3 Binder Superfamily
Class Class 260

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
Prothrombin Inhibitor Ximelagatran Family 5 48
Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Family 9 83
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Efegatran Family 9 47
Prothrombin Inhibitor LB30812 Family 12 36
Neuromedin-K receptor Ligand Senktide Family 15 22
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor Sibrafiban Family 4 6
Integrin beta-3 Inhibitor L-709780 Family 9 10
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Integrin beta-3 Inhibitor SKF-107260 Family 5 8
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Coagulation factor X and Cationic trypsin inhibitor AC1L1JML f... 11 32
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-b... 3 4
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-6-[[2-(4... 2 11
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7301018... 4 3
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7961093... 1 0
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 7 18
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(1R,5S,11S,1... 8 2
Integrin alpha-V and Integrin beta-5 inhibitor 2-[(2S,5R,8S,11... 2 1
Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-... 4 4
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074AY6... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
Caspase-1 inhibitor (3S)-3-[[(4S,7S)-7-[(2-fluorobenzoyl)amino... 4 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-[... 8 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-0757VU... 13 39
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
4'-phosphopantetheinyl transferase ffp and Beta-lactamase inhi... 1 0
tanedioate NP ZINC08790785 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00227461 CHEMBL422486 Bioactive SureCN7285056
CFAMM00227455 DNC003546 Investigative Drug DMP-757
CFAMM00227462 DNC008322 Investigative Drug cyclo-[-Arg-Gly-Asp-Amp22-]
CFAMM00227466 DNC008321 Investigative Drug cyclo-[-Arg-Gly-Asp-Amp26-]
CFAMM00227479 DNC004274 Investigative Drug Ro-43-5054

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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