| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... | 14 | 498 |
| Reverse transcriptase Inhibitor Nevirapine Family | 23 | 640 |
| Toll-like receptor 7 Ligand Imiquimod Family | 3 | 237 |
| Acetylcholinesterase Inhibitor Tacrine Family | 12 | 515 |
| Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... | 8 | 98 |
| Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family | 10 | 145 |
| Histamine H1 receptor Ligand Triprolidine Family | 19 | 316 |
| Histamine H1 receptor Ligand Mizolastine Family | 14 | 603 |
| Transient receptor potential cation channel subfamily V member... | 15 | 158 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Transient receptor potential cation channel subfamily V member... | 16 | 295 |
| Neuropeptide Y receptor type 5 Ligand CGP71683A Family | 5 | 74 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Transient receptor potential cation channel subfamily V member... | 6 | 66 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Cyclin-dependent kinase 4 Inhibitor PD-332991 Family | 13 | 155 |
| Glucagon receptor Ligand Dwlip-gcgrrx Family | 5 | 26 |
| Reverse transcriptase Inhibitor Dapivirine Family | 5 | 72 |
| D(1B) dopamine receptor Ligand LE-300 Family | 65 | 452 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 35 | 270 |
| Amg 423 family | 7 | 47 |
| GDC-0349 family | 44 | 77 |
| 5-hydroxytryptamine receptor 2A Ligand RP-68303 Family | 7 | 44 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 8 | 55 |
| Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family | 9 | 29 |
| Tryptase Inhibitor Babim Family | 12 | 90 |
| Class II cytokine receptor Ligand IL-10 Family | 7 | 45 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| 5-hydroxytryptamine receptor 2B Ligand MT-500 Family | 8 | 39 |
| Corticotropin-releasing factor receptor 1 Ligand R121919 Family | 26 | 84 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 11 | 138 |
| Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... | 2 | 11 |
| Carbonic anhydrase 2 Inhibitor Cyanamide Family | 2 | 32 |
| Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... | 10 | 43 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... | 13 | 14 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... | 6 | 48 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Vascular endothelial growth factor receptor 1 and Vascular end... | 6 | 23 |
| Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... | 5 | 14 |
| Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... | 7 | 117 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... | 7 | 102 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3-... | 7 | 2 |
| Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... | 7 | 11 |
| Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... | 2 | 5 |
| 5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... | 5 | 4 |
| Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... | 4 | 9 |
| Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... | 5 | 3 |
| Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... | 7 | 5 |
| Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... | 6 | 5 |
| Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family | 14 | 103 |
| Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... | 4 | 8 |
| Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... | 17 | 29 |
| Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... | 7 | 39 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 19 | 103 |
| Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... | 43 | 17 |
| Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... | 7 | 11 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... | 1 | 6 |
| DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... | 2 | 6 |
| Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... | 7 | 30 |
| Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... | 2 | 9 |
| Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... | 28 | 47 |
| Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... | 3 | 9 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... | 2 | 30 |
| Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... | 1 | 2 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... | 22 | 18 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... | 7 | 7 |
| Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... | 6 | 10 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... | 4 | 11 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... | 2 | 29 |
| Aromatase Inhibitor NSC-356781 Family | 3 | 10 |
| Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... | 5 | 4 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 9 | 24 |
| Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... | 5 | 37 |
| Histamine H4 receptor Ligand A-943931 Family | 14 | 11 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... | 2 | 4 |
| Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... | 7 | 18 |
| Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... | 2 | 2 |
| Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... | 19 | 108 |
| Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... | 5 | 16 |
| Urotensin-2 receptor Ligand Palosuran Family | 4 | 4 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... | 6 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... | 5 | 2 |
| Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... | 18 | 21 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 4 | 22 |
| Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... | 5 | 35 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... | 3 | 2 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Reverse transcriptase Inhibitor PT-109 Family | 6 | 7 |
| Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... | 5 | 2 |
| Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... | 2 | 3 |
| Amine oxidase [flavin-containing] A Inhibitor 1-(3-(4-chlorobe... | 3 | 12 |
| Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... | 4 | 3 |
| Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... | 3 | 1 |
| Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... | 4 | 2 |
| Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... | 6 | 10 |
| Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... | 1 | 0 |
| 5-hydroxytryptamine receptor 3A and D(2) dopamine receptor Lig... | 1 | 0 |
| Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... | 14 | 22 |
| Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... | 6 | 16 |
| Protein kinase C alpha type Inhibitor Dequalinium Analogue Family | 1 | 10 |
| Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... | 62 | 27 |
| Choline kinase alpha Inhibitor Bisquinolinium Derivative Family | 10 | 7 |
| Corticotropin-releasing factor receptor 1 ligand 4-N-(2-bromo-... | 9 | 48 |
| Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... | 7 | 3 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 3 | 9 |
| Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... | 3 | 0 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 7 | 4 |
| Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... | 8 | 8 |
| Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family | 13 | 8 |
| Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... | 4 | 12 |
| Bloom syndrome protein inhibitor SR 57227A family | 2 | 12 |
| Epidermal growth factor receptor ligand AGN-PC-076GVG family | 8 | 1 |
| Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... | 11 | 0 |
| Cathepsin K and Potassium voltage-gated channel subfamily H me... | 3 | 1 |
| Cathepsin K and Potassium voltage-gated channel subfamily H me... | 5 | 1 |
| Epidermal growth factor receptor ligand AGN-PC-076GXM family | 6 | 0 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 3 | 11 |
| 5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family | 10 | 8 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Thyrotropi... | 1 | 2 |
| Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... | 4 | 5 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... | 7 | 1 |
| Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... | 4 | 2 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 5 | 0 |
| Dihydrofolate reductase inhibitor AC1LAKQL family | 3 | 1 |
| Survival motor neuron protein inhibitor CHEMBL1581561 family | 1 | 3 |
| Mitogen-activated protein kinase 13 and Mitogen-activated prot... | 5 | 0 |
| Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... | 1 | 7 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 5 | 1 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 0 |
| Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... | 3 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 0 |
| Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... | 5 | 4 |
| Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... | 7 | 6 |
| Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... | 5 | 17 |
| Neuropeptide Y receptor type 5 ligand SureCN8898853 family | 2 | 3 |
| Mu-type opioid receptor and Kappa-type opioid receptor ligand ... | 3 | 0 |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... | 1 | 1 |
| Sodium-dependent dopamine transporter and Sodium-dependent ser... | 2 | 10 |
| Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... | 4 | 0 |
| Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... | 10 | 6 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... | 3 | 0 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 1 | 1 |
| Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... | 5 | 3 |
| Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... | 14 | 12 |
| Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... | 5 | 0 |
| Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... | 1 | 4 |
| Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 9 | 2 |
| Mitogen-activated protein kinase 13 and Mitogen-activated prot... | 2 | 0 |
| Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... | 2 | 0 |
| Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... | 3 | 0 |
| Cathepsin K and Cathepsin S inhibitor SureCN4138353 family | 3 | 0 |
| C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... | 3 | 1 |
| LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... | 4 | 0 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 4 | 0 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 7 | 0 |
| Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family | 2 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-077JWI family | 7 | 1 |
| Adenosine kinase inhibitor AGN-PC-074DKZ family | 1 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... | 1 | 2 |
| Reverse transcriptase/RNaseH inhibitor 181305-52-2 family | 1 | 0 |
| P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family | 3 | 2 |
| Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... | 2 | 0 |
| 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... | 1 | 2 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
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How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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