CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1102
Family Name Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl)-butyramide Family
No. of Seeds 26 No. of Other Members 101
Family Centroid CFAMM00227582 Functional Category Investigative Drug with Natural Product
Superfamily Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl)-butyramide Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 140
Nitric oxide synthase, endothelial Inhibitor Acclaim Family 2 15
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Substance-P receptor Ligand R 673 Family 2 127
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Reverse transcriptase Inhibitor L-697,661 Family 1 25
Chymase Inhibitor Y-40613 Family 11 56
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Vascular endothelial growth factor receptor 1 and Vascular end... 6 28
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Fatty-acid amide hydrolase 1 Inhibitor 7-phenyl-1-(5-phenyloxa... 3 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
Fatty-acid amide hydrolase 1 inhibitor SureCN1471727 family 2 19
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Neprilysin and Natriuretic peptides A inhibitor (2S)-2-[[1-[[(... 3 3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 11 0
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 4jj ... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 5a f... 2 1
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Cholesteryl ester transfer protein inhibitor 2-(4-chloro-2,3-d... 1 1
Coagulation factor X and Plasma kallikrein inhibitor (2R)-N-[2... 1 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Reverse transcriptase/RNaseH inhibitor 3-[2-(4,7-dichloro-1,3-... 1 5
Cellular tumor antigen p53 inhibitor CHEMBL1592002 family 1 0
Cholesteryl ester transfer protein inhibitor AGN-PC-09QKST family 1 3
Cholesteryl ester transfer protein inhibitor AGN-PC-09QM3I family 1 9
Reverse transcriptase/RNaseH inhibitor 3-[2-(4,7-difluoro-1,3-... 3 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AGN-PC-074D... 4 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN14736... 4 0
Cholesteryl ester transfer protein inhibitor N-[4-(5-chloro-7-... 1 0
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
Reverse transcriptase/RNaseH inhibitor 3-[2-(1-benzofuran-2-yl... 1 1
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00227748 CHEMBL124422 Bioactive SureCN6786026
CFAMM00227579 CHEMBL2112690 Bioactive SureCN6786689
CFAMM00227578 CHEMBL124577 Bioactive SureCN6784544
CFAMM00227710 CHEMBL127596 Bioactive SureCN6783228
CFAMM00227662 CHEMBL338659 Bioactive SureCN6781677
CFAMM00227602 CHEMBL123899 Bioactive AGN-PC-0753DL
CFAMM00227633 CHEMBL2112727 Bioactive SureCN6783477
CFAMM00227709 CHEMBL127570 Bioactive SureCN6780791
CFAMM00227721 CHEMBL262890 Bioactive AGN-PC-03TSDX
CFAMM00227583 CHEMBL124362 Bioactive SureCN6781427
CFAMM00227632 CHEMBL2112724 Bioactive SureCN6780444
CFAMM00227659 CHEMBL333810 Bioactive AGN-PC-03TSDN
CFAMM00227683 CHEMBL2112734 Bioactive SureCN6783528
CFAMM00227631 CHEMBL2112722 Bioactive SureCN6783472
CFAMM00227749 CHEMBL2112700 Bioactive SureCN6784569
CFAMM00227658 CHEMBL125642 Bioactive N-[3-(2-ethyl-1,3-benzoxazol-7-yl)propyl]cyclopropanecarboxamide
CFAMM00227607 DNC003594 Investigative Drug N-(3-Benzooxazol-7-yl-propyl)-propionamide
CFAMM00227689 DNC003555 Investigative Drug N-[3-(2-Ethyl-benzooxazol-7-yl)-propyl]-acetamide
CFAMM00227582 DNC003570 Investigative Drug N-(3-Benzooxazol-7-yl-propyl)-butyramide
CFAMM00227667 DNC003582 Investigative Drug N-(3-Benzooxazol-7-yl-propyl)-acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44437 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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