CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1105
Family Name Platelet-activating factor receptor Ligand L-652731 Family
No. of Seeds 5 No. of Other Members 116
Family Centroid CFAMM00228015 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Oxi4503 Superfamily
Class Class 1241

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
DNA topoisomerase 2-beta Inhibitor Etoposide Family 3 29
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand Dienestrol Family 35 440
DNA Binder Methoxsalen Family 10 1638
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Salicin family 5 629
Sodium/glucose cotransporter 2 Inhibitor Empagliflozin Family 32 52
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Arachidonate 5-lipoxygenase Inhibitor Lonapalene Family 1 31
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Glucokinase Inhibitor R7201 Family 22 105
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Acolbifene family 10 115
TS-071 family 8 36
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Endothelin-1 receptor Ligand PD156707 Family 41 211
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Androgen receptor Ligand 2'-hydroxy-3-methoxy-biphenyl-4-carbo... 2 13
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Beta-secretase 1 Inhibitor Eckol Family 6 40
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 6
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 4 5
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Potassium voltage-gated channel subfamily A member 3 ligand CH... 10 11
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Low affinity sodium-glucose cotransporter and Sodium/glucose c... 1 0
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Cytochrome P450 1A1 and Cytochrome P450 1B1 inhibitor 1,2,4-tr... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
Stromelysin-1 inhibitor SureCN9248631 family 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1
Androgen receptor ligand AGN-PC-00BPQ5 family 1 3
Receptor-type tyrosine-protein phosphatase C and Tyrosine-prot... 1 0
Epidermal growth factor receptor ligand NSC650565 family 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Phenols and Derivatives Metabolite 2-Chloro-1,3-dimethoxy-5-me... 1 3
Lignans and Norlignans Metabolite cis-Miyabenol C Family 3 0
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
Benzene and Substituted Derivatives Metabolite 1,3,5-Trimethox... 2 17
NP (1r,2r,4s)-2-(2-methoxyphenyl)-1,3,3-trimethylbicyclo[2.2.1... 3 0
ahydropyrano[3,2-c]chromene NP ZINC04023039 Family 16 2
Putative NP ZINC32123984 Family 2 2
NP 4-(2,3,4-trimethoxyphenyl)-3,4-dihydro-2h-benzo[g]chromene-... 2 1
3-(2,3-dihydro-1,4-benzodioxin-6-yl)chromene-4-thione NP 3-(2,... 1 0
2-(4-methoxyphenyl)-10,10-dimethyl-1,3,9-trioxaspiro[5.5]undec... 4 19
(2R,3S)-2-[3,4-bis(phenylmethoxy)phenyl]-8-bromo-3,5,7-tris(ph... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00227865 CHEMBL287709 Bioactive SureCN10797170
CFAMM00227843 CHEMBL2408678 Bioactive (2R,3R)-2-(3-ethoxy-4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
CFAMM00227842 CHEMBL2408677 Bioactive [(2R,3R)-5,7-diacetyloxy-2-(3,4-diacetyloxyphenyl)-3,4-dihydro-2H-chromen-3-yl] acetate
CFAMM00228015 DNC003560 Investigative Drug L-652731

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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