CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1107
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor CC-1088 Family
No. of Seeds 2 No. of Other Members 16
Family Centroid CFAMM00228252 Functional Category Investigative Drug with Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Apremilast Superfamily
Class Class 1059

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Zucapsacin family 7 177
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 1 4
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Apre... 1 4
Substance-P receptor Ligand DA-5018 Family 14 73
D(3) dopamine receptor Ligand U-99194A Family 7 33
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Transient receptor potential cation channel subfamily V member... 3 18
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
Cholinesterase and Acetylcholinesterase inhibitor AGN-PC-009M2... 1 6
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 4-(3... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 4 4
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Putative NP ZINC14589285 Family 2 1
Putative NP ZINC04041531 Family 40 0
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC20113203 Family 4 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 2
Putative NP ZINC02099241 Family 12 0
Putative NP ZINC00519603 Family 8 1
Putative NP ZINC02134473 Family 4 0
3-(3,4-dimethoxyphenyl)-3-[3-(7-methoxy-4,8-dimethyl-2-oxochro... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228252 DNC003569 Investigative Drug CC-1088

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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