CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1110
Family Name Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 11B1, mitochondrial Inhibitor Abiraterone Family
No. of Seeds 5 No. of Other Members 23
Family Centroid CFAMM00228303 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Oestrogen receptor and Estrogen receptor beta Binder Superfamily
Class Class 1979

Cousin Family NamesSeedsMembers
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 4 8
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 11 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN8345160 fa... 1 2
Urokinase-type plasminogen activator and Plasminogen inhibitor... 1 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 1 0
Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2
Pyridines and Derivatives Metabolite Rotundine A Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228310 CHEMBL79829 Bioactive (3R,5S,10S,13S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CFAMM00228317 CHEMBL460178 Bioactive AGN-PC-04XDWZ
CFAMM00228295 CHEMBL150263 Bioactive (3S,5S,10S,13S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
CFAMM00228285 DNC009634 Investigative Drug 6-Pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-ol
CFAMM00228303 DNC003575 Investigative Drug ABIRATERONE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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