CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1112
Family Name Farnesyltransferase beta subunit, putative and Protein farnesyltransferase subunit beta Inhibitor L-778123 Family
No. of Seeds 20 No. of Other Members 81
Family Centroid CFAMM00228418 Functional Category Investigative Drug
Superfamily Farnesyltransferase beta subunit, putative and Protein farnesyltransferase subunit beta Inhibitor L-778123 Superfamily
Class Class 1486

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Histamine H3 receptor Ligand SCH79687 Family 11 29
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-im... 2 30
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 2 1
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Histamine H3 receptor ligand SureCN2878688 family 8 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Protein farnesyltransferase alpha subunit and Protein farnesyl... 5 0
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
Translocator protein inhibitor CHEMBL2331870 family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Cathepsin K inhibitor SureCN4138062 family 7 0
Mitogen-activated protein kinase 8 inhibitor 4-[(6-chloro-1-ox... 1 1
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Sodium- and chloride-dependent glycine transporter 1 and Potas... 3 0
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228331 CHEMBL100798 Bioactive 4-[[5-[[[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]-(2-morpholin-4-ylethyl)amino]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228390 CHEMBL1209775 Bioactive SureCN3574602
CFAMM00228357 CHEMBL194072 Bioactive naphthyridone 3d
CFAMM00228422 CHEMBL23939 Bioactive 1-(3-chlorophenyl)-4-[[3-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]imidazol-4-yl]methyl]piperazin-2-one
CFAMM00228389 CHEMBL184488 Bioactive 1-(3-chlorophenyl)-6-[[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methylamino]methyl]-4-oxopyridine-3-carbonitrile
CFAMM00228349 CHEMBL125162 Bioactive 4-[[5-[[(2S)-2-butyl-4-(3-chlorophenyl)-5-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228375 CHEMBL98147 Bioactive 4-[[5-[[3-aminopropyl-[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228329 CHEMBL99205 Bioactive 4-[[5-[[[(3S)-1-(3-chlorophenyl)-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228348 CHEMBL99381 Bioactive SureCN7936711
CFAMM00228328 CHEMBL163739 Bioactive AGN-PC-00FHUG
CFAMM00228387 CHEMBL125648 Bioactive SureCN445627
CFAMM00228400 CHEMBL101788 Bioactive 4-[[5-[[[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]-(2-piperazin-1-ylethyl)amino]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228367 CHEMBL333317 Bioactive 4-[[5-[[(2S)-4-(3-chlorophenyl)-2-methyl-5-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228393 CHEMBL125558 Bioactive 4-[[5-[[(2S)-4-(3-chlorophenyl)-2-(ethylsulfonylmethyl)-5-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228412 CHEMBL312137 Bioactive SureCN2352908
CFAMM00228366 CHEMBL316726 Bioactive SureCN7933812
CFAMM00228398 CHEMBL2110187 Bioactive 4-[[5-[[[(4S)-2-(3-chlorophenyl)-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228411 CHEMBL318438 Bioactive 4-[[5-[[[(3S)-1-[(2-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]amino]methyl]imidazol-1-yl]methyl]benzonitrile
CFAMM00228418 DNC003581 Investigative Drug L-778123

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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