CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID112
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phenyl-1-propyl-3,7-dihydro-purine-2,6-dione Family
No. of Seeds 12 No. of Other Members 213
Family Centroid CFAMM00181378 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily
Class Class 1027

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Translocator protein Inhibitor Emapunil Family 7 89
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Plinabulin family 1 0
CC-486 family 7 103
Toll-like receptor 7 Ligand GS-9620 Family 2 4
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Histamine H3 receptor Ligand SCH79687 Family 11 29
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Adenosine deaminase Inhibitor FR221647 Family 1 4
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 14
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5856722 family 3 16
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
Adenosine receptor A1 ligand 4-[5-(8-cyclopentyl-2,6-dioxo-1-p... 3 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Adenosine receptor A3 and Nuclear receptor ROR-gamma ligand (8... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 11 1
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 13 2
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Adenosine receptor A2b ligand (8Z)-8-(6-oxopyridin-3-ylidene)-... 1 0
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 1 0
Cathepsin K inhibitor SureCN4138062 family 7 0
Prothrombin inhibitor N-(2-aminoethyl)-2-[5-[[3-(benzylsulfony... 17 5
Adenosine receptor A2b ligand N-(4-chlorophenyl)-2-[(5Z)-5-(2,... 1 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Adenosine receptor A1 and Adenosine receptor A2b ligand 1-meth... 6 4
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand FSCPX ... 3 0
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Sodium- and chloride-dependent glycine transporter 1 and Potas... 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-02ZKZ9... 9 12
Amiloride-sensitive sodium channel subunit alpha ligand AGN-PC... 6 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-5-b... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00181451 CHEMBL175215 Bioactive SureCN9840392
CFAMM00181452 DNC011883 Investigative Drug 1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione
CFAMM00181458 DNC003651 Investigative Drug 8-PHENYL THEOPHYLLINE
CFAMM00181486 DNC003664 Investigative Drug 1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione
CFAMM00181436 DNC004201 Investigative Drug 1-Phenethyl-3,7-dihydro-purine-2,6-dione
CFAMM00181378 DNC003644 Investigative Drug 8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione
CFAMM00181411 DNC011756 Investigative Drug 1,3-Diethyl-8-phenyl-3,7-dihydro-purine-2,6-dione
CFAMM00181506 DNC011633 Investigative Drug 8-Phenyl-3,7-dihydro-purine-2,6-dione
CFAMM00181404 DNC000106 Investigative Drug 8-amino-9-benzylguanine
CFAMM00181484 DNC011603 Investigative Drug 1-Methyl-8-phenyl-3,7-dihydro-purine-2,6-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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