CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1124
Family Name Vascular endothelial growth factor receptor 2 Ligand 6-(1h-benzoimidazol-2-yl)-benzocyclohepten-7-one Family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00228559 Functional Category Investigative Drug
Superfamily Vascular endothelial growth factor receptor 2 Ligand 6-(1h-benzoimidazol-2-yl)-benzocyclohepten-7-one Superfamily
Class Class 1983

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
JNJ-39439335 family 5 11
BIBT986 family 7 96
SB989 family 17 91
CC-486 family 7 103
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Tryptase Inhibitor Babim Family 12 90
Cathepsin D Inhibitor 1h-benoximidazole-2-carboxylic Acid Family 1 15
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Transient receptor potential cation channel subfamily M member... 9 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 5
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Glucagon receptor ligand SureCN2666184 family 7 2
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Beta-secretase 1 inhibitor SureCN8284926 family 2 0
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor CHEM... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN3535776 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228559 DNC003612 Investigative Drug 6-(1H-Benzoimidazol-2-yl)-benzocyclohepten-7-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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