CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1125
Family Name Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his-oh Family
No. of Seeds 33 No. of Other Members 41
Family Centroid CFAMM00228611 Functional Category Investigative Drug
Superfamily Insulin-degrading enzyme inhibitor Bacitracin, Renin inhibitor Remikiren Superfamily
Class Class 414

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
CBP-501 family 7 8
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Lethal factor Inhibitor GM6001 Family 50 435
Renin Inhibitor Enalkiren Family 56 44
Caspase-9 Inhibitor Z-lehd-fmk Family 1 0
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Glycylpeptide N-tetradecanoyltransferase Inhibitor SC-58272 Fa... 2 11
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial Inhibitor Methyl 3-(1-benz... 3 12
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor penicillin deriv. 71 family 1 2
Pol polyprotein and Protease inhibitor 161186-52-3 family 3 3
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Glucagon-like peptide 1 receptor ligand CHEMBL1092373 family 5 2
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S... 4 0
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Pol polyprotein inhibitor AC1LA3L0 family 3 2
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 1
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Pol polyprotein and Renin inhibitor U-75875 family 12 1
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Placenta growth factor inhibitor CHEMBL1689479 family 4 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN9... 3 10
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Gastrin/cholecystokinin type B receptor ligand CHEMBL2386886 f... 1 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Gastrin-releasing peptide receptor ligand (2S)-N-[(2S)-1-[[(2S... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-(3-imidazo... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor (2S)-2... 2 4
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Neuropeptide Y receptor type 2 ligand CHEMBL411765 family 1 0
Angiotensin-converting enzyme 2 inhibitor MLN-4760 family 1 3
Epidermal growth factor receptor ligand CHEMBL437469 family 1 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Growth hormone secretagogue receptor type 1 ligand CHEMBL52599... 1 0
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16g... 1 0
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 0
Carboxypeptidase A1 inhibitor 2-(1H-imidazol-5-yl)-3-phenylpro... 1 0
Putative NP ZINC40309668 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228619 CHEMBL265270 Bioactive methyl (2S)-2-[[(2S,3S)-2-[[(4S)-3-hydroxy-4-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-(3-methylbutanoylamino)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoate
CFAMM00228572 CHEMBL329933 Bioactive (2S)-1-[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[(4S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00228599 CHEMBL446156 Bioactive (2S)-2-[[(2S,3S)-2-[[(2S,4S,5S)-4-hydroxy-5-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]propanoyl]amino]-7-methyl-2-propan-2-yloctanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
CFAMM00228625 CHEMBL500468 Bioactive GHRELIN
CFAMM00228566 CHEMBL2371846 Bioactive (2S)-6-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(3S,4S)-3-hydroxy-4-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
CFAMM00228571 CHEMBL386972 Bioactive (2S)-2-[[(2S,3S)-2-[[(2S,5S)-4-hydroxy-5-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-7-methyl-2-propan-2-yloctanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
CFAMM00228584 CHEMBL407670 Bioactive 85139-12-4
CFAMM00228604 CHEMBL2310887 Bioactive CHEMBL2310887
CFAMM00228570 CHEMBL2028988 Bioactive (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-hydroxy-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid
CFAMM00228565 CHEMBL159130 Bioactive 2-amino-5-[2-[[1-[[1-[[1-cyclohexyl-3-hydroxy-6-methyl-5-(3-methylbutylcarbamoyl)heptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid
CFAMM00228610 CHEMBL504776 Bioactive CHEMBL504776
CFAMM00228576 CHEMBL430065 Bioactive (2S)-2-[[(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid
CFAMM00228589 CHEMBL177904 Bioactive tert-butyl (2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,5S,7R)-7-[[(2S,3S)-1-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
CFAMM00228603 CHEMBL2310888 Bioactive CHEMBL2310888
CFAMM00228595 CHEMBL412702 Bioactive CHEMBL412702
CFAMM00228569 CHEMBL438100 Bioactive (2S)-N-[(2S)-1-[[(2S)-1-[[(4S)-1-[[(2S,3S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-[(2S)-3-(1H-imidazol-5-yl)-2-(3-methylbutanoylamino)propanoyl]pyrrolidine-2-carboxamide
CFAMM00228602 CHEMBL216847 Bioactive methyl (2S)-2-[[(2S)-2-[[(2S,3S)-2-[[3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-2-hydroxy-5-methylhexanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
CFAMM00228563 CHEMBL264339 Bioactive (2S)-N-[(2S)-1-[[(2S)-1-[[1-[[(2S,3S)-1-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carboxamide
CFAMM00228587 CHEMBL2028990 Bioactive (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-5-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-5-oxo-1-phenylpentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1-[(2S)-3-(1H-imidazol-5-yl)-2-(3-methylbutanoylamino)propanoyl]pyrrolidine-2-carboxamide
CFAMM00228562 CHEMBL526723 Bioactive CHEMBL526723
CFAMM00228580 CHEMBL1790494 Bioactive tert-butyl (2S)-2-[[(2S)-1-[[(2S)-1-[[(4S,5S,7S)-7-[[(2S,3S)-1-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]-5-hydroxy-2,8-dimethylnonan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
CFAMM00228593 CHEMBL268309 Bioactive (2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]propanoic acid
CFAMM00228620 CHEMBL269752 Bioactive (2S)-1-[(2S)-2-[[(2S)-2-amino-2-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CFAMM00228611 DNC003617 Investigative Drug (H-261)Boc-His-Pro-Phe-His-Leu(OH)-Val-Ile-His-OH
CFAMM00228573 DNC003745 Investigative Drug Pro-His-Pro-Phe-His-Leu(CH2NH)Val-Ile-His-Lys

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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