CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID1133
Family Name 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhibitor UK-356618 Family
No. of Seeds 40 No. of Other Members 87
Family Centroid CFAMM00228680 Functional Category Investigative Drug
Superfamily 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhibitor UK-356618 Superfamily
Class Class 1988

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Neuromedin-K receptor Ligand Osanetant Family 38 192
Dopamine reuptake Inhibitor Amineptine Family 2 5
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Voltage-gated sodium channel Ligand Lacosamide Family 1 10
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Substance-P receptor Ligand Vestipitant Family 14 137
Pan-DAC Inhibitor AR-42 Family 21 153
Bavisant family 9 65
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Aldose reductase Inhibitor Alrestatin Family 2 11
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Major prion protein Inhibitor Anti-prp Antibodies Family 1 6
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Prothrombin Inhibitor Efegatran Family 9 47
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor LB30812 Family 12 36
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor Ppack Family 5 4
Neuromedin-K receptor Ligand Senktide Family 15 22
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-nal-agly-ile-v... 3 2
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-[1-(4-isobut... 1 7
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Chymase Inhibitor Chymostatin Family 2 3
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2-nap... 3 3
Arachidonate 5-lipoxygenase Inhibitor Phenanthrene-3-carboxyli... 7 4
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Prothrombin and Coagulation factor X inhibitor AGN-PC-074UE2 f... 1 0
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 5 9
Cathepsin K inhibitor [(3S)-4,4-dimethyl-1-(naphthalene-2-carb... 4 9
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Cathepsin S inhibitor SureCN6857538 family 2 12
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 2 0
Coagulation factor X inhibitor (6S,8aS)-2-benzhydrylsulfonyl-N... 5 5
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 1
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Oxytocin receptor and Vasopressin V1a receptor ligand L 365209... 6 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 3 1
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Neprilysin inhibitor SureCN489232 family 3 9
Cathepsin S inhibitor SureCN7062841 family 7 7
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Peptide deformylase inhibitor (2R)-2-[[formyl(hydroxy)amino]me... 2 1
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4
Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpip... 6 0
Matrix metalloproteinase-9 inhibitor (3R)-2-[ethoxy-(4-phenylp... 4 15
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Neutrophil collagenase and Collagenase 3 inhibitor n-[[2-methy... 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-2-[4-(4-fluor... 1 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
NS3 inhibitor SureCN14450642 family 4 7
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Dipeptidyl peptidase 4 inhibitor (2S,3S)-3-amino-4-[(3S)-3-flu... 1 5
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 3 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 4 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
B1 bradykinin receptor ligand N-[(1R)-1-[4-(3-chloro-2-propano... 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 162
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-2-... 6 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Type-2 angiotensin II receptor ligand SureCN3515167 family 2 0
Neprilysin inhibitor SureCN7437961 family 2 6
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor [4-[[2-[[4-... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Sigma non-opioid intracellular receptor 1 ligand tert-butyl N-... 1 9
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor (2R,3R)... 1 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 13
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 3 4
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Legumain-like protease inhibitor N-[(2R)-1-[[(2S)-1-[2-(2-amin... 6 7
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Prothrombin inhibitor 1-(2-amino-3,3-diphenylpropanoyl)-N-[(3-... 1 1
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Neutrophil collagenase and Macrophage metalloelastase inhibito... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 4
B1 bradykinin receptor ligand 4-(4-oxothiochromen-3-yl)-N-[(1R... 1 2
Melanocortin receptor 4 ligand SureCN3093411 family 1 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 2 2
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 6 4
Disintegrin and metalloproteinase domain-containing protein 17... 1 1
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Putative fructose-1,6-bisphosphate aldolase and Nuclear recept... 1 6
Collagenase 3 and Interstitial collagenase inhibitor (4R)-1-[[... 1 0
carboxamide NP (s)-n1-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228731 CHEMBL152855 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-(2-phenylpropan-2-ylamino)butan-2-yl]-N'-hydroxy-2-(3-phenylpropyl)butanediamide
CFAMM00228757 CHEMBL154440 Bioactive (2R)-N-[(2S)-1-(benzhydrylamino)-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-[3-(4-phenylphenyl)propyl]butanediamide
CFAMM00228770 CHEMBL305780 Bioactive (2R)-N'-hydroxy-N-[(2R)-1-(methylamino)-1-oxo-3-(4-phenylphenyl)propan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00228696 CHEMBL71618 Bioactive (2R)-N'-hydroxy-N-[(2R)-1-(methylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00228689 CHEMBL345447 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-[3-(4-phenylphenyl)propyl]butanediamide
CFAMM00228708 CHEMBL503231 Bioactive (2R)-N'-hydroxy-N-[(2S)-1-[[(1S)-2-methoxy-1-phenylethyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide
CFAMM00228674 CHEMBL144169 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(naphthalene-2-carbonylamino)butanediamide
CFAMM00228694 CHEMBL1162926 Bioactive (E)-N-[(2R)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N,5-dimethyl-5-(methylamino)hex-2-enamide
CFAMM00228673 CHEMBL153914 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1S)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-(3-phenylpropyl)butanediamide
CFAMM00228748 CHEMBL443818 Bioactive (2R)-N-[(2S)-1-(benzhydrylamino)-3,3-dimethyl-1-oxobutan-2-yl]-2-[3-(3-fluoro-4-phenylphenyl)propyl]-N'-hydroxybutanediamide
CFAMM00228728 CHEMBL326489 Bioactive (2R)-N'-hydroxy-N-[(2S)-1-[[(R)-methoxy(phenyl)methyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide
CFAMM00228753 CHEMBL415074 Bioactive (2R)-N-[(2S)-3-cyclohexyl-1-oxo-1-(2-phenylethylamino)propan-2-yl]-2-[3-(4-ethylphenyl)propyl]-N'-hydroxybutanediamide
CFAMM00228678 CHEMBL71800 Bioactive (2R)-N-[(2R)-1-(benzylamino)-1-oxo-3-(4-phenylphenyl)propan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00228692 CHEMBL154044 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide
CFAMM00228671 CHEMBL152277 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-2-[3-(3-fluoro-4-phenylphenyl)propyl]-N'-hydroxybutanediamide
CFAMM00228759 CHEMBL328005 Bioactive (2R)-N-[(2S)-3-cyclohexyl-1-oxo-1-(2-phenylethylamino)propan-2-yl]-2-(3-cyclohexylpropyl)-N'-hydroxybutanediamide
CFAMM00228677 CHEMBL154551 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-N'-hydroxy-2-(3-phenylpropyl)butanediamide
CFAMM00228691 CHEMBL279078 Bioactive (2S,3R)-N-hydroxy-2-methyl-N'-[(2S)-1-(methylamino)-1-oxo-3-(5,6,7,8-tetrahydronaphthalen-1-yl)propan-2-yl]-3-(2-methylpropyl)butanediamide
CFAMM00228704 CHEMBL156830 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-oxo-1-[[(1R)-1-phenylethyl]amino]butan-2-yl]-2-[3-(9H-fluoren-2-yl)propyl]-N'-hydroxybutanediamide
CFAMM00228765 CHEMBL144001 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(naphthalen-2-ylmethylamino)butanediamide
CFAMM00228758 CHEMBL70492 Bioactive (2R)-N'-hydroxy-N-[(2R)-1-(methylamino)-3-naphthalen-1-yl-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
CFAMM00228680 DNC003632 Investigative Drug UK-356618

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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