CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1137
Family Name Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyridin-3-yl)biphenyl-3-ol Family
No. of Seeds 5 No. of Other Members 34
Family Centroid CFAMM00228950 Functional Category Investigative Drug
Superfamily Estradiol 17-beta-dehydrogenase 1 and DNA topoisomerase 1 Binder Superfamily
Class Class 1991

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 1
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Squalene synthase Inhibitor ER-119884 Family 2 3
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Beta-secretase 1 inhibitor CHEMBL2152919 family 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Renin inhibitor SureCN6042213 family 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Fatty-acid amide hydrolase 1 inhibitor [3-[(2-chloropyridin-3-... 3 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0
dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00228963 CHEMBL323312 Bioactive 2-[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(3-methyl-1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
CFAMM00228962 CHEMBL289023 Bioactive AGN-PC-073JZ7
CFAMM00228959 DNC003641 Investigative Drug L-791943
CFAMM00228979 DNC011101 Investigative Drug 4-[1-(4'-Methoxybiphenyl-4-yl)propyl]pyridine
CFAMM00228950 DNC010811 Investigative Drug 4'-(6-Methoxypyridin-3-yl)biphenyl-3-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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