CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1140
Family Name Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6-benzyloxy-9h-purin-2-ylamine Family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00229097 Functional Category Investigative Drug
Superfamily Cyclin-dependent kinase 2 and Methylated-DNA--protein-cysteine methyltransferase Binder Superfamily
Class Class 1696

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Cyclin-dependent kinase 2 Inhibitor 2-anilino-6-cyclohexylmeth... 4 13
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Glucagon receptor ligand SureCN2647807 family 3 7
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00229096 CHEMBL485756 Bioactive 6-[[3-(aminomethyl)phenyl]methoxy]-7H-purin-2-amine
CFAMM00229092 DNC003948 Investigative Drug 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine
CFAMM00229097 DNC003646 Investigative Drug 6-Benzyloxy-9H-purin-2-ylamine
CFAMM00229099 DNC003958 Investigative Drug 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543