CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID115
Family Name Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-1115 Family
No. of Seeds 34 No. of Other Members 26
Family Centroid CFAMM00181586 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily
Class Class 1027

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Toll-like receptor 7 Ligand GS-9620 Family 2 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN1... 6 16
Adenosine receptor A1 ligand 4-[5-(8-cyclopentyl-2,6-dioxo-1-p... 3 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Histamine H4 receptor ligand SureCN602132 family 1 8
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Adenosine receptor A1 and Adenosine receptor A2b ligand (4-nit... 8 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Adenosine receptor A1 and Adenosine receptor A2b ligand 1-meth... 6 4
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand FSCPX ... 3 0
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00181564 CHEMBL11036 Bioactive 96445-35-1
CFAMM00181577 CHEMBL11002 Bioactive SureCN7038994
CFAMM00181567 CHEMBL359066 Bioactive 4-[(8-cyclohexyl-2,6-dioxo-1-propyl-7H-purin-3-yl)methyl]benzenesulfonyl fluoride
CFAMM00181592 CHEMBL486479 Bioactive 1-propyl-8-[4-[4-[[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]sulfonylphenyl]-3,7-dihydropurine-2,6-dione
CFAMM00181559 CHEMBL545362 Bioactive N-[4-(dimethylamino)butyl]-4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)benzenesulfonamide;hydrochloride
CFAMM00181588 DNC009732 Investigative Drug PSB-0788
CFAMM00181569 DNC001364 Investigative Drug SPT
CFAMM00181587 DNC009733 Investigative Drug PSB-09120
CFAMM00181568 DNC006739 Investigative Drug PSB-601
CFAMM00181586 DNC009736 Investigative Drug PSB-1115
CFAMM00181561 DNC012609 Investigative Drug PD-115199
CFAMM00181583 DNC000113 Investigative Drug 8-sulfophenyl theophylline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

43386 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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