CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1170
Family Name Farnesyltransferase beta subunit, putative and Protein farnesyltransferase subunit beta Inhibitor ABT-839 Family
No. of Seeds 24 No. of Other Members 82
Family Centroid CFAMM00230284 Functional Category Investigative Drug with Natural Product
Superfamily Genome polyprotein and Delta-type opioid receptor Binder Superfamily
Class Class 2006

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Tryptase Inhibitor APC-366 Family 2 12
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 18
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Neuromedin-K receptor Ligand Senktide Family 15 22
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85053 F... 6 8
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Voltage-dependent calcium channel gamma-1 subunit Ligand 4-(3,... 6 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Cathepsin K inhibitor [(3S)-4,4-dimethyl-1-(naphthalene-2-carb... 4 9
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Pol polyprotein inhibitor 2-[(2R,3S)-3-[[(2R)-3-(benzenesulfin... 15 15
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Caspase-1 inhibitor CHEMBL114791 family 1 0
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 inhibit... 1 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 9
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Neprilysin inhibitor SureCN489232 family 3 9
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686807 f... 7 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Pol polyprotein inhibitor AC1LALX3 family 2 0
Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Replication protein E1 inhibitor AC1LAK2U family 3 10
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 7 18
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 12 5
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family 9 4
Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-... 4 4
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Angiotensin-converting enzyme and Neprilysin inhibitor (5R,7S)... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 2 0
Angiotensin-converting enzyme and Leukotriene A-4 hydrolase in... 7 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0
Neutrophil elastase inhibitor 3-[[(2S)-3-methyl-1-oxo-1-[2-[(1... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Neprilysin inhibitor AGN-PC-02K4O6 family 2 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 1 5
Retinal dehydrogenase 1 and 15-hydroxyprostaglandin dehydrogen... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Breast cancer type 1 susceptibility protein inhibitor (2S)-2-[... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
Leukotriene A-4 hydrolase and Angiotensin-converting enzyme in... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 2 0
Kinesin-like protein KIF11 inhibitor methyl (2S)-2-[[(2R)-2-am... 1 1
Receptor-type tyrosine-protein phosphatase C ligand SureCN6261... 1 1
NP Methyl 5-((2s,3s,4r)-4-benzamido-3-chlorotetrahydrothiophen... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00230241 CHEMBL344100 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-ethylsulfanylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230267 CHEMBL144175 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-phenylsulfanylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230334 CHEMBL352068 Bioactive SureCN7284258
CFAMM00230286 CHEMBL421269 Bioactive (2S)-2-[[4-[[N-[(3,5-difluorophenyl)methyl]anilino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230253 CHEMBL144536 Bioactive (2S)-2-[[4-[[[(2S)-1-tert-butylsulfanyl-3-cyclohexylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230320 CHEMBL295798 Bioactive SureCN7277469
CFAMM00230239 CHEMBL344771 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-hydroxypropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230231 CHEMBL145417 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-hydroxypropan-2-yl]amino]methyl]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230305 CHEMBL501939 Bioactive (2S)-2-[[(4R,7S,13S)-13-[[(2S)-3-(4-carbamoyl-2,6-dimethylphenyl)-2-methylpropanoyl]amino]-7-[(4-fluorophenyl)methyl]-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carbonyl]amino]-3-phenylpropanoic acid
CFAMM00230238 CHEMBL342872 Bioactive 2-[[(2S)-2-(naphthalene-2-carbonylamino)-3-phenylpropanoyl]amino]-4-sulfanylbutanoic acid
CFAMM00230251 CHEMBL112189 Bioactive (2S)-2-[[2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230264 CHEMBL321981 Bioactive (2S)-2-[[2-[[(2S)-2-[[2-[(4-cyanophenyl)methylsulfanyl]acetyl]amino]-3-methylpentyl]-(naphthalen-1-ylmethyl)amino]acetyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230325 CHEMBL79718 Bioactive (2S)-3-[(4-methylphenyl)methylsulfanyl]-2-[[(2S)-2-(naphthalen-1-ylmethyl)-3-sulfanylpropanoyl]amino]propanoic acid
CFAMM00230237 CHEMBL144745 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-ethylsulfanylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfonylbutanoic acid
CFAMM00230250 CHEMBL358363 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-ethylsulfonylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230282 CHEMBL342315 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-(2-methylphenyl)sulfanylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230323 CHEMBL145317 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-cyclohexylsulfanylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230262 CHEMBL145699 Bioactive (2S)-2-[[4-[[[(2S)-1-cyclohexyl-3-ethylsulfonylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfonylbutanoic acid
CFAMM00230288 CHEMBL332149 Bioactive (2S)-2-[[4-[(N-benzylanilino)methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230301 CHEMBL144183 Bioactive (2S)-2-[[4-[[[(1R)-1-cyclohexyl-2-hydroxyethyl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230242 CHEMBL424119 Bioactive (2S)-2-[[4-[[[(1S)-1-cyclohexyl-2-hydroxyethyl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230268 CHEMBL343435 Bioactive (2S)-2-[[4-[[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00230284 DNC003723 Investigative Drug ABT-839

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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