CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1175
Family Name Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4-one Family
No. of Seeds 3 No. of Other Members 30
Family Centroid CFAMM00230462 Functional Category Investigative Drug with Natural Product
Superfamily Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4-one Superfamily
Class Class 2009

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Renin Inhibitor CP-305202 Family 9 30
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Lanosterol synthase inhibitor (4-bromophenyl)-[6-[6-[methyl(pr... 1 1
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
Aromatase inhibitor isoflavone deriv. 5m family 1 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 0
Aromatase inhibitor AGN-PC-0AKO1M family 1 0
Quinolines and Derivatives Metabolite Azacridone A Family 1 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
NP Agn-pc-01km7v Family 6 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00230489 DNC004776 Investigative Drug 2-Pyridin-3-yl-benzo[h]chromen-4-one
CFAMM00230462 DNC003738 Investigative Drug 2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one
CFAMM00230466 DNC014716 Investigative Drug 6-Methyl-2-pyridin-3-yl-chromen-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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