CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1178
Family Name 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic receptor Ligand BMY-7378 Family
No. of Seeds 18 No. of Other Members 12
Family Centroid CFAMM00230561 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic receptor Ligand BMY-7378 Superfamily
Class Class 516

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 3 1
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
Survival motor neuron protein inhibitor N-(2-methoxyphenyl)-2-... 1 1
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Calcitonin gene-related peptide type 1 receptor ligand 2-(4-me... 4 4
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00230545 CHEMBL342355 Bioactive (3aS,7aR)-2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
CFAMM00230541 CHEMBL1242912 Bioactive 8-[[(2S,4S)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]-8-azaspiro[4.5]decane-7,9-dione
CFAMM00230556 CHEMBL60583 Bioactive 8-[2-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
CFAMM00230548 CHEMBL59315 Bioactive AGN-PC-004XNT
CFAMM00230554 CHEMBL46881 Bioactive AP-685/41280891
CFAMM00230547 CHEMBL305038 Bioactive 1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-3,4-dihydroquinolin-2-one
CFAMM00230546 CHEMBL1241557 Bioactive 8-[[(2S,4R)-4-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-phenyl-1,3-dioxolan-2-yl]methyl]-8-azaspiro[4.5]decane-7,9-dione
CFAMM00230561 DNC003753 Investigative Drug BMY-7378

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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