CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1180
Family Name Thromboxane-A synthase Inhibitor CGS-22652 Family
No. of Seeds 37 No. of Other Members 95
Family Centroid CFAMM00230684 Functional Category Investigative Drug
Superfamily Thromboxane-A synthase Inhibitor CGS-22652 Superfamily
Class Class 1128

Cousin Family NamesSeedsMembers
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
HIV-1 protease Inhibitor Tipranavir Family 25 10
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Prothrombin Inhibitor Ximelegatran Family 8 157
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Coagulation factor X Inhibitor Otamixaban Family 9 21
Potassium-competitive acid Inhibitor TAK-438 Family 2 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Integrin beta-1 and Integrin alpha-4 Inhibitor MK-0668 Family 46 20
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 2 9
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Endothelin B receptor Ligand IRL-2500 Family 34 87
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 4 19
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Pol polyprotein inhibitor AGN-PC-0AAPKK family 2 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
Thromboxane-A synthase inhibitor 4-chloro-N-[8-pyridin-3-yl-5-... 1 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Thromboxane A2 receptor and Thromboxane-A synthase ligand 3-[(... 3 0
Pol polyprotein inhibitor AGN-PC-0AAOIM family 4 0
Thromboxane A2 receptor and Thromboxane-A synthase ligand (E)-... 2 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 3 0
Pol polyprotein inhibitor AC1LADJW family 8 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Pol polyprotein inhibitor Lysine Sulfonamide 6h family 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Thromboxane-A synthase inhibitor 7-[(2S,3R)-3-pyridin-3-yl-2-b... 1 1
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 1 0
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6374908 f... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 0
Free fatty acid receptor 1 ligand 3-[4-[2-(7-chloroquinolin-4-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[2-(2,6-dichloro-3-meth... 3 0
Thromboxane-A synthase inhibitor SureCN9825871 family 6 3
Cytochrome P450 2C19 inhibitor AGN-PC-07CPMJ family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A and Outer membrane ... 2 0
Receptor-type tyrosine-protein phosphatase beta ligand AGN-PC-... 1 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-[[2-[3... 4 0
heptanamide NP ZINC08740384 Family 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00230638 CHEMBL136738 Bioactive SureCN9733134
CFAMM00230724 CHEMBL63090 Bioactive SureCN8308584
CFAMM00230665 CHEMBL136762 Bioactive SureCN9734008
CFAMM00230678 CHEMBL341686 Bioactive AGN-PC-00FHHX
CFAMM00230657 CHEMBL339269 Bioactive 6-(4-(2-(4-Chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hexanoic acid
CFAMM00230671 CHEMBL139372 Bioactive SureCN9732350
CFAMM00230730 CHEMBL136371 Bioactive SureCN9732662
CFAMM00230623 CHEMBL125519 Bioactive AC1O6WLN
CFAMM00230697 CHEMBL435590 Bioactive SureCN9732786
CFAMM00230637 CHEMBL134686 Bioactive SureCN9732334
CFAMM00230677 CHEMBL126577 Bioactive (E)-6-[6-[(4-chlorophenyl)sulfonylamino]-5,6,7,8-tetrahydronaphthalen-2-yl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230722 CHEMBL138328 Bioactive SureCN9732973
CFAMM00230642 CHEMBL295121 Bioactive AGN-PC-073NM8
CFAMM00230669 CHEMBL136904 Bioactive SureCN9869646
CFAMM00230682 CHEMBL126196 Bioactive (E)-6-[4-[2-[(2-amino-2-oxoethyl)-(4-chlorophenyl)sulfonylamino]ethyl]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230695 CHEMBL339568 Bioactive (E)-6-[4-[(4-chlorophenyl)sulfonylamino]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230701 CHEMBL137402 Bioactive SureCN9732886
CFAMM00230714 CHEMBL126334 Bioactive 3-[(E)-2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]-2-pyridin-3-ylethenyl]benzoic acid
CFAMM00230727 CHEMBL127683 Bioactive (E)-6-[3-[[(4-chlorophenyl)sulfonylamino]methyl]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230694 CHEMBL340396 Bioactive (E)-6-[4-[[(4-chlorophenyl)sulfonylamino]methyl]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230653 CHEMBL130470 Bioactive (E)-6-[4-[2-[(4-chlorophenyl)sulfonyl-ethylamino]ethyl]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230693 CHEMBL64005 Bioactive (4S)-8-[(4-chlorophenyl)sulfonylamino]-4-(3-pyridin-3-ylpropyl)octanoic acid
CFAMM00230706 CHEMBL277689 Bioactive Samixogrel
CFAMM00230719 CHEMBL43745 Bioactive AGN-PC-073NM7
CFAMM00230686 CHEMBL65378 Bioactive AGN-PC-02ITH6
CFAMM00230639 CHEMBL127380 Bioactive (E)-6-[3-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]-6-pyridin-3-ylhex-5-enoic acid
CFAMM00230652 CHEMBL136934 Bioactive SureCN9733855
CFAMM00230679 CHEMBL137505 Bioactive 8-[(4-azidophenyl)sulfonylamino]-4-(3-pyridin-3-ylpropyl)octanoic acid
CFAMM00230731 CHEMBL345105 Bioactive SureCN9733051
CFAMM00230611 CHEMBL65187 Bioactive SureCN9709519
CFAMM00230684 DNC003758 Investigative Drug CGS-22652

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26365 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 
Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543