CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1181
Family Name Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family
No. of Seeds 11 No. of Other Members 13
Family Centroid CFAMM00230744 Functional Category Investigative Drug
Superfamily Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Superfamily
Class Class 65

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Plitidepsin family 15 5
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Integrin beta-3 Inhibitor FK-633 Family 2 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Plasmepsin-2 Inhibitor KNI-10079 Family 19 8
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 8 5
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Caspase-6 and Caspase-3 inhibitor (4S)-5-[[1-[[(3S)-2-hydroxy-... 1 24
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H3 receptor ligand SureCN4319687 family 8 15
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Caspase-3 and Caspase-1 inhibitor (3S)-3-[[(2S)-3-methyl-2-[(2... 1 3
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Pol polyprotein inhibitor MK-944a family 6 1
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Neprilysin inhibitor SureCN389939 family 5 6
Pol polyprotein inhibitor AC1NQUJL family 10 11
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Pol polyprotein inhibitor (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-... 11 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
NS3 inhibitor CHEMBL201121 family 1 4
Pol polyprotein inhibitor L-689,502 family 17 2
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Motilin receptor ligand SureCN74051 family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
C-C chemokine receptor type 5 ligand 4-[4-[[4-[(5R)-3-cyclohex... 4 2
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Pol polyprotein inhibitor AC1LA3AI family 5 9
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-4-o... 4 5
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Pol polyprotein inhibitor AC1L9XVT family 4 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Caspase-1 inhibitor 3-[[(2S)-4-hydroxy-1-[(2S)-3-methyl-2-[[(E... 1 0
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
Caspase-1 inhibitor 3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethox... 1 3
Renin inhibitor (4S,5S,7S)-5-amino-N-butyl-7-[[4-tert-butyl-3-... 2 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Renin inhibitor N-[2-[[(2R)-1-[[(2S,3R,4S)-3,4-dihydroxy-6-met... 1 0
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
Pol polyprotein inhibitor AC1MHYEO family 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00230745 CHEMBL74166 Bioactive AC1LAA2G
CFAMM00230738 CHEMBL133324 Bioactive N-[(2S,3S)-4-[2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-[(2-naphthalen-1-yloxyacetyl)amino]butanediamide
CFAMM00230750 CHEMBL283522 Bioactive (2R)-N-tert-butyl-1-[(3S)-2-hydroxy-3-[[(2S)-3-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-4-phenylbutanoyl]pyrrolidine-2-carboxamide
CFAMM00230736 CHEMBL24855 Bioactive (2S)-N-[(2S)-4-[(2R)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-[(2-naphthalen-2-yloxyacetyl)amino]butanediamide
CFAMM00230742 CHEMBL283735 Bioactive (2S)-N-[(2S)-4-[(2R)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-[(2-naphthalen-1-yloxyacetyl)amino]butanediamide
CFAMM00230741 CHEMBL1790706 Bioactive (2S,3S,4S,5S)-6-cyclohexyl-3,4-dihydroxy-N-[(1R)-2-hydroxy-1H-inden-1-yl]-5-[[(2S,3R)-3-hydroxy-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-2-propan-2-ylhexanamide
CFAMM00230747 CHEMBL335391 Bioactive (2S)-N-tert-butyl-1-[(2S,3S)-2-hydroxy-3-[[(2S)-3-methyl-2-[(2-naphthalen-1-yloxyacetyl)amino]butanoyl]amino]-4-phenylbutanoyl]pyrrolidine-2-carboxamide
CFAMM00230740 CHEMBL536761 Bioactive SureCN7298598
CFAMM00230753 CHEMBL334985 Bioactive (2S)-N-[(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-[(2-naphthalen-2-yloxyacetyl)amino]butanediamide
CFAMM00230752 CHEMBL70388 Bioactive AC1LAA2D
CFAMM00230744 DNC003761 Investigative Drug PS-777621

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45584 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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