CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1182
Family Name 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic receptor Ligand SNAP-8719 Family
No. of Seeds 19 No. of Other Members 88
Family Centroid CFAMM00230791 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic receptor Ligand SNAP-8719 Superfamily
Class Class 2012

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Androgen receptor ligand CHEMBL182412 family 2 8
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 0
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00230853 CHEMBL193620 Bioactive SureCN6752779
CFAMM00230817 CHEMBL192099 Bioactive SureCN6754644
CFAMM00230852 CHEMBL293539 Bioactive SureCN6581749
CFAMM00230857 CHEMBL291908 Bioactive AGN-PC-009TVB
CFAMM00230779 CHEMBL57364 Bioactive 8-[2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
CFAMM00230843 CHEMBL239680 Bioactive AGN-PC-068CEB
CFAMM00230842 CHEMBL239681 Bioactive AGN-PC-0471ES
CFAMM00230856 CHEMBL56804 Bioactive AGN-PC-009UFB
CFAMM00230798 CHEMBL556313 Bioactive SureCN6752801
CFAMM00230849 CHEMBL293968 Bioactive 8-[2-(4-phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione
CFAMM00230862 CHEMBL299022 Bioactive 2-[4-[2-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)ethyl]piperazin-1-yl]benzonitrile
CFAMM00230828 CHEMBL56869 Bioactive AGN-PC-0081HU
CFAMM00230855 CHEMBL56805 Bioactive AGN-PC-004YRQ
CFAMM00230805 CHEMBL446180 Bioactive 8-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
CFAMM00230820 CHEMBL58476 Bioactive SureCN6579957
CFAMM00230797 CHEMBL299691 Bioactive SureCN6751064
CFAMM00230840 CHEMBL57882 Bioactive AGN-PC-004QDN
CFAMM00230761 CHEMBL57747 Bioactive SureCN9844858
CFAMM00230791 DNC003765 Investigative Drug SNAP-8719

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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