CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1183
Family Name Potassium voltage-gated channel subfamily A member 5 Ligand N-phenethyl-2-(toluene-4-sulfonylamino)-benzamide Family
No. of Seeds 8 No. of Other Members 32
Family Centroid CFAMM00230903 Functional Category Investigative Drug
Superfamily Potassium voltage-gated channel subfamily A member 5 and Voltage-dependent T-type calcium channel subunit alpha-1I Binder Superfamily
Class Class 2013

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Histone deacetylase 1 Inhibitor PXD101 Family 3 24
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1A and Sigma non-opioid intracell... 7 28
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Caspase-3 Inhibitor 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-di... 5 35
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase Inhibitor SC-74020 Family 1 21
Aldose reductase Inhibitor Inhibitor Idd 384 Family 1 3
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-morp... 6 81
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
5-hydroxytryptamine receptor 6 Ligand N-(3-(2-aminoethyl)pheny... 8 25
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 7 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Interstitial collagenase and Neutrophil collagenase inhibitor ... 3 9
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 8
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[1-[(2,4-di... 20 3
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[1-(naphtha... 13 5
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-dichlo... 8 0
C-C chemokine receptor type 2 ligand SureCN2988733 family 14 17
Neutrophil elastase inhibitor SureCN7448165 family 2 4
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2,2,3,... 2 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Neprilysin inhibitor AGN-PC-047EOR family 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Coagulation factor X and Trypsin-1 inhibitor SureCN6161266 family 2 28
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
B1 bradykinin receptor ligand SureCN1712821 family 5 3
Transient receptor potential cation channel subfamily V member... 9 38
C-C chemokine receptor type 2 ligand SureCN2983871 family 9 8
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 2 1
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 4 8
Bifunctional epoxide hydrolase 2 inhibitor N-(2-chlorophenyl)-... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor (E)-2... 2 0
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltra... 5 10
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
Coagulation factor X and Trypsin-1 inhibitor SureCN7690621 family 12 20
C-C chemokine receptor type 2 ligand 2-(cyclohexanecarbonylami... 1 0
C-C chemokine receptor type 2 ligand AGN-PC-03L0X5 family 13 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 7 0
Prothrombin and Trypsin-1 inhibitor N-[4-[(diaminomethylidenea... 1 6
Carbonic anhydrase 2 inhibitor N-[(4-nitrophenyl)methyl]-4-sul... 1 2
Prostaglandin E2 receptor EP1 subtype and Prostaglandin D2 rec... 1 4
C-C chemokine receptor type 8 ligand 3-pyrrolidin-1-ylpropyl 4... 2 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 1 0
B1 bradykinin receptor and Potassium voltage-gated channel sub... 1 1
Orexin receptor type 2 ligand SureCN1039013 family 1 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin F2-alp... 5 1
C-C chemokine receptor type 2 ligand AGN-PC-03L0Z6 family 1 1
B1 bradykinin receptor ligand AGN-PC-04TG1P family 4 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS0Z family 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor KB-74... 2 0
Prothrombin and Proteinase-activated receptor 1 ligand (2S)-N-... 2 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor AGN-PC-0... 2 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 3 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 8
Histidinol dehydrogenase inhibitor 2-(1-benzyl-2-oxo-5-thiomor... 1 4
Chymase and Chymotrypsinogen A inhibitor SureCN7836048 family 2 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 1 2
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00230886 CHEMBL63627 Bioactive N-[[4-(dimethylamino)phenyl]methyl]-4-sulfamoylbenzamide
CFAMM00230971 CHEMBL270959 Bioactive 2-amino-N-[2-oxo-2-[[(1S,2R)-2-[(4-sulfamoylbenzoyl)amino]cyclohexyl]amino]ethyl]-5-(trifluoromethyl)benzamide
CFAMM00231000 CHEMBL259848 Bioactive N-benzyl-4-[(phenylsulfonyl)amino]benzamide
CFAMM00230903 DNC003768 Investigative Drug N-Phenethyl-2-(toluene-4-sulfonylamino)-benzamide
CFAMM00230922 DNC003812 Investigative Drug N-Benzyl-2-(toluene-4-sulfonylamino)-benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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