CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1184
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1h-benzoimidazol-4-yloxy)-ethyl]-benzyl-amine Family
No. of Seeds 17 No. of Other Members 100
Family Centroid CFAMM00231030 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1h-benzoimidazol-4-yloxy)-ethyl]-benzyl-amine Superfamily
Class Class 2014

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Potassium-transporting ATPase alpha chain 1 Inhibitor Rabepraz... 4 113
Histamine H1 receptor Ligand Astemizole Family 7 240
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Beta-3 adrenergic receptor ligand SureCN7137270 family 1 1
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Neuropeptide Y receptor type 5 and Alpha-1A adrenergic recepto... 8 2
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Transient receptor potential M8 protein ligand (3E)-3-[5-[2-(t... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Beta-3 adrenergic receptor ligand (5Z)-5-[[4-[4-[[(2S)-2-hydro... 2 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Metabotropic glutamate receptor 5 ligand SureCN4297614 family 2 5
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 1 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 0
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
Interstitial collagenase and Matrilysin inhibitor (2R)-N'-hydr... 1 0
B2 bradykinin receptor ligand SureCN7976932 family 2 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 1 0
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Transient receptor potential cation channel subfamily V member... 18 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
D(2) dopamine receptor ligand 4-bromo-6-[2-[4-(2-methoxyphenyl... 2 3
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Cytochrome P450 2C19 and Cytochrome P450 1A2 inhibitor 2-hepty... 4 4
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2-(dimethyla... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919926 f... 1 0
Coagulation factor X inhibitor AGN-PC-07C2VY family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231074 CHEMBL89037 Bioactive 4-[2-(benzylamino)ethoxy]-6-chloro-1,3-dihydrobenzimidazole-2-thione
CFAMM00231088 CHEMBL201843 Bioactive SureCN7411798
CFAMM00231032 CHEMBL313851 Bioactive SureCN5729167
CFAMM00231122 CHEMBL314174 Bioactive SureCN7332955
CFAMM00231129 CHEMBL87192 Bioactive SureCN8120094
CFAMM00231016 CHEMBL93753 Bioactive (8S)-8-[(benzylamino)methyl]-3,6,7,8-tetrahydro-1H-pyrano[2,3-e]benzimidazol-2-one
CFAMM00231107 CHEMBL329398 Bioactive SureCN7341090
CFAMM00231106 CHEMBL36060 Bioactive CGP-12177A
CFAMM00231042 CHEMBL265752 Bioactive 2-(PHENOXYMETHYL)-4-[3-(1-PIPERIDINYL)PROPOXY]-1-[3-(4-PIPERIDINYL)PROPYL]-1H-BENZIMIDAZOLE
CFAMM00231076 CHEMBL327782 Bioactive 4-[2-(benzylamino)ethoxy]-1,3-dihydrobenzimidazole-2-thione
CFAMM00231091 CHEMBL420986 Bioactive (8R)-8-[(benzylamino)methyl]-3,6,7,8-tetrahydro-1H-pyrano[2,3-e]benzimidazol-2-one
CFAMM00231047 CHEMBL93779 Bioactive 8-[(benzylamino)methyl]-3,6,7,8-tetrahydro-1H-pyrano[2,3-e]benzimidazol-2-one
CFAMM00231131 CHEMBL86504 Bioactive SureCN8218533
CFAMM00231030 DNC003771 Investigative Drug [2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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