CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1185
Family Name Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand 4-(6,7-dimethoxy-quinolin-3-yl)-benzoic Acid Family
No. of Seeds 2 No. of Other Members 17
Family Centroid CFAMM00231138 Functional Category Investigative Drug with Natural Product
Superfamily Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand 4-(6,7-dimethoxy-quinolin-3-yl)-benzoic Acid Superfamily
Class Class 2015

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Tivozanib family 4 6
8-aminoquinoline Inhibitor Tafenoquine Family 1 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4C and cAMP-speci... 12 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
B2 bradykinin receptor ligand SureCN6640854 family 7 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QHF0 family 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Transient receptor potential cation channel subfamily V member... 6 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Transient receptor potential cation channel subfamily V member... 3 2
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]... 1 0
Integrase and Serine/threonine-protein kinase pim-1 inhibitor ... 3 0
8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-8-one NP 6,7-dime... 47 0
2-en-1-one NP (e)-3-(benzo[d][1,3]dioxol-5-yl)-1-(6-bromo-2-me... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231138 DNC003772 Investigative Drug 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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