CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1191
Family Name Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand 7-fluoro-3-thiophen-3-yl-quinoline Family
No. of Seeds 5 No. of Other Members 48
Family Centroid CFAMM00231301 Functional Category Investigative Drug
Superfamily Cytochrome P450 3A4 and Cytochrome P450 11B1, mitochondrial Binder Superfamily
Class Class 1800

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Urokinase-type plasminogen activator Inhibitor Thieno[2,3-b]py... 1 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Histamine H3 receptor Ligand ST-1025 Family 2 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Aromatase inhibitor 2-(2-chloropyridin-4-yl)-4-pyridin-3-yl-1,... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophe... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Protein kinase C theta type and Protein kinase C delta type in... 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231247 DNC003820 Investigative Drug 5,7-Dimethyl-3-thiophen-3-yl-quinoline
CFAMM00231285 DNC003832 Investigative Drug 3-Thiophen-3-yl-quinoline
CFAMM00231301 DNC003782 Investigative Drug 7-Fluoro-3-thiophen-3-yl-quinoline
CFAMM00231306 DNC003785 Investigative Drug 5-Fluoro-3-thiophen-3-yl-quinoline
CFAMM00231273 DNC003795 Investigative Drug 6,7-Difluoro-3-thiophen-3-yl-quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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