CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1193
Family Name Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphthyridin-4-one Family
No. of Seeds 7 No. of Other Members 15
Family Centroid CFAMM00231343 Functional Category Investigative Drug with Natural Product
Superfamily Tubulin beta chain and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 148

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
DNA topoisomerase 2-beta Inhibitor Nalidixic Acid Family 2 5
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
XL-888 family 16 85
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Tyrosine-protein kinase JAK2 inhibitor SureCN2455673 family 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231329 DNC014687 Investigative Drug 5,7-Dimethyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one
CFAMM00231352 DNC005778 Investigative Drug 3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol
CFAMM00231343 DNC014675 Investigative Drug 7-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one
CFAMM00231333 DNC005680 Investigative Drug (2,6-Diamino-pyridin-3-yl)-phenyl-methanone
CFAMM00231342 DNC003811 Investigative Drug 7-Methyl-2-propyl-[1,8]naphthyridin-4-ol
CFAMM00231340 DNC003818 Investigative Drug 7-Bromo-2-phenyl-[1,8]naphthyridin-4-ol
CFAMM00231353 DNC003786 Investigative Drug 7-Dimethylamino-2-phenyl-[1,8]naphthyridin-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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