CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1197
Family Name Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-indole-5-carboxamidine Family
No. of Seeds 3 No. of Other Members 69
Family Centroid CFAMM00231395 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-indole-5-carboxamidine Superfamily
Class Class 731

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
JNJ-39439335 family 5 11
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49
Coagulation factor VII inhibitor 2-[(3E)-3-(5-carbamimidoyl-1,... 3 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Coagulation factor VII inhibitor AGN-PC-0763KB family 1 1
Estrogen receptor ligand 4-[3,5-bis(4-hydroxyphenyl)-1-propylp... 1 0
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Coagulation factor X and Urokinase-type plasminogen activator ... 8 10
Coagulation factor VII and Tissue factor inhibitor 2-[3-(5-car... 3 2
Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5
Coagulation factor X and Prothrombin inhibitor (2Z)-3-benzyl-2... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6292901 f... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Urokinase-type plasminogen activator and Tissue-type plasminog... 1 4
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Coagulation factor X and Prothrombin inhibitor SureCN6289429 f... 1 0
Carbonic anhydrase 2 inhibitor 6-hydroxy-1H-indole-2-sulfonami... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Carbonic anhydrase 4 and Carbonic anhydrase 2 inhibitor 5,10-d... 3 1
Proto-oncogene tyrosine-protein kinase Src and cAMP-dependent ... 2 0
Indoles Metabolite 7-Hydroxyheptaphylline Family 4 0
2-[2-(4-hydroxyphenyl)ethyl]-6-methylpyridin-1-ium-3-ol NP 2-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231364 CHEMBL339902 Bioactive 6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indole-5-carboximidamide
CFAMM00231392 CHEMBL96433 Bioactive 1o2g
CFAMM00231395 DNC003815 Investigative Drug 2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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