CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1199
Family Name Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family
No. of Seeds 30 No. of Other Members 170
Family Centroid CFAMM00231557 Functional Category Investigative Drug
Superfamily Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Superfamily
Class Class 2020

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
E7050 family 2 13
Indeglitazar family 3 39
MK-6096 family 3 69
Arachidonate 5-lipoxygenase-activating protein Inhibitor AM103... 14 12
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 23 8
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Leukotriene B4 receptor 1 ligand AGN-PC-07ZF09 family 3 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(4-ethox... 4 5
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 6 5
Integrin beta-3 and Integrin alpha-V inhibitor 2-(2,3-dihydro-... 13 1
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Cytochrome P4... 5 0
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 4 40
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(dime... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Integrin beta-3 and Integrin alpha-V inhibitor (3S,7S)-7-hydro... 5 1
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 8 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Integrin beta-3 and Integrin alpha-V inhibitor SureCN8335217 f... 2 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 14 8
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(3,5-di... 1 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6223678 f... 14 1
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6220269 f... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 22 1
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 1 13
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03OERH f... 1 0
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Progesterone receptor ligand (8S,11R,13S,14S,16R,17S)-17-(cycl... 5 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 2
Thromboxane-A synthase inhibitor (E)-7-[4-[5-[(2S,4S,5R)-5-[(Z... 3 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 1 0
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453385 ... 5 0
Thromboxane-A synthase inhibitor SureCN9045578 family 1 12
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-074ASZ f... 5 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Peroxisome proliferator-activated receptor gamma and Cytochrom... 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Proteinase-activated receptor 1 ligand ethyl N-[(1R,3aR,4aR,6R... 1 4
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 2
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Mitogen-activated protein kinase 14 and Dual specificity mitog... 2 4
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Acetylcholinesterase inhibitor ethyl (4R)-5-amino-4-(4-methoxy... 1 9
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Renin inhibitor SureCN7300793 family 2 5
Bile acid receptor ligand pyridin-4-yl (1R,3aS,5aR,5bR,7aR,9S,... 1 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Integrin beta-3 and Integrin alpha-V inhibitor SureCN244675 fa... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[3,4-di... 2 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Free fatty acid receptor 1 ligand AGN-PC-0A9RM5 family 1 0
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[(3-meth... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 8
Arachidonate 5-lipoxygenase inhibitor 4-(furan-3-yl)-7-[[5-(4-... 2 1
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
7-(4-hydroxy-2-oxo-2H-chromen-3-yl)chromeno[4',3':3,4]cyclopen... 2 0
5-(4-methoxyphenyl)-4-oxo-1H-pyrido[2,3-d]pyrimidin-2-olate NP... 1 0
4-[(4-pyridin-1-ium-2-ylpiperazin-1-yl)methyl]chromen-2-one NP... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231527 CHEMBL425717 Bioactive SureCN6422137
CFAMM00231492 CHEMBL425299 Bioactive AGN-PC-03OESF
CFAMM00231656 CHEMBL1688868 Bioactive SureCN546550
CFAMM00231519 CHEMBL37751 Bioactive SureCN6178862
CFAMM00231622 CHEMBL226357 Bioactive 3-pyridin-3-yl-4-[4-[3-(pyridin-2-ylamino)propoxy]phenyl]butanoic acid
CFAMM00231499 CHEMBL225743 Bioactive AGN-PC-03OEPL
CFAMM00231505 CHEMBL226253 Bioactive AGN-PC-03NXRI
CFAMM00231655 CHEMBL1688869 Bioactive SureCN545837
CFAMM00231491 CHEMBL459646 Bioactive 4-[4-[2-[[(2R)-2-(6-aminopyridin-3-yl)-2-hydroxyethyl]amino]ethoxy]phenyl]-2-(2-methylpropyl)benzoic acid
CFAMM00231498 CHEMBL226045 Bioactive SureCN6264385
CFAMM00231561 CHEMBL225897 Bioactive AGN-PC-03OEPP
CFAMM00231574 CHEMBL393778 Bioactive SureCN1400490
CFAMM00231648 CHEMBL1688867 Bioactive SureCN545554
CFAMM00231601 CHEMBL390740 Bioactive AGN-PC-03OERP
CFAMM00231661 CHEMBL606371 Bioactive (2S)-3-[4-[3-(pyridin-2-ylamino)propoxy]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid
CFAMM00231647 CHEMBL238944 Bioactive SureCN1400528
CFAMM00231461 CHEMBL1688870 Bioactive SureCN545032
CFAMM00231523 CHEMBL416493 Bioactive SureCN6657173
CFAMM00231476 CHEMBL240437 Bioactive SureCN1400677
CFAMM00231503 CHEMBL393593 Bioactive SureCN1400445
CFAMM00231559 CHEMBL314022 Bioactive SureCN328727
CFAMM00231537 CHEMBL38348 Bioactive SureCN6176301
CFAMM00231612 CHEMBL226050 Bioactive 2-[2-[3-fluoro-4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl]cyclopropyl]acetic acid
CFAMM00231459 CHEMBL425116 Bioactive SureCN1400636
CFAMM00231521 CHEMBL421533 Bioactive SureCN979390
CFAMM00231637 CHEMBL87429 Bioactive SureCN243383
CFAMM00231487 CHEMBL36346 Bioactive AGN-PC-073KNY
CFAMM00231535 CHEMBL239352 Bioactive SureCN3007852
CFAMM00231610 CHEMBL219944 Bioactive SureCN1400495
CFAMM00231557 DNC003825 Investigative Drug SB-265123

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27521 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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