CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1202
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Ligand 3-(2-benzylamino-ethoxy)-phenol Family
No. of Seeds 25 No. of Other Members 50
Family Centroid CFAMM00231735 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A Ligand MN-305 Superfamily
Class Class 576

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Serotonin re-uptake Inhibitor Paroxetine Family 6 19
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Muscarinic acetylcholine receptor M1 Ligand GSK573719 Family 2 0
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Oestrogen receptor and Tyrosine-protein phosphatase non-recept... 92 21
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
C-C chemokine receptor type 5 Ligand N-(2-(4-chlorobenzyloxy)-... 3 13
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tubulin beta chain Inhibitor Colchinol Family 3 109
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0
Estrogen receptor and Estrogen receptor beta ligand CHEMBL1087... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 10 6
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 4
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sigma non-opioid intracellular receptor 1 ligand (1S,4R,5R)-7-... 2 7
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-[(4... 3 53
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand Desac... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Estrogen receptor and Estrogen receptor beta ligand SureCN8476... 2 1
Membrane primary amine oxidase inhibitor 2-hydrazinyl-1-(4-met... 1 2
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Mu-type opioid receptor ligand 2-[[2-[(2R)-2-ethyl-4-(4-fluoro... 1 3
Orexin receptor type 2 ligand N-benzyl-2-[2-(3,4-dimethoxyphen... 5 12
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
C-C chemokine receptor type 4 ligand AGN-PC-07AKPI family 1 5
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0
Putative NP ZINC38201335 Family 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231715 CHEMBL134448 Bioactive AGN-PC-075MB5
CFAMM00231713 CHEMBL149697 Bioactive AGN-PC-075SK6
CFAMM00231729 CHEMBL134489 Bioactive oxalic acid;(2R)-2-[(4-phenylbutylamino)methyl]-3,4-dihydro-2H-chromen-7-ol
CFAMM00231706 CHEMBL101285 Bioactive AGN-PC-074TGU
CFAMM00231735 DNC003833 Investigative Drug 3-(2-Benzylamino-ethoxy)-phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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