CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1209
Family Name Disintegrin and metalloproteinase domain-containing protein 17 and Tumor necrosis factor Inhibitor PKF-241-466 Family
No. of Seeds 8 No. of Other Members 7
Family Centroid CFAMM00231923 Functional Category Investigative Drug
Superfamily Bacterial outer membrane Inhibitor Polymyxin B Superfamily
Class Class 607

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Puromycin-sensitive aminopeptidase Inhibitor CHR-2797 Family 1 2
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Efegatran Family 9 47
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Chymase Inhibitor Chymostatin Family 2 3
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Pol polyprotein inhibitor (2S)-2-[[2-(2,5-dioxoimidazolidin-4-... 2 0
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 1
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Renin inhibitor [(2R)-1-[[(2S,3S,5R)-6-(butylamino)-1-cyclohex... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Neprilysin inhibitor SureCN489232 family 3 9
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Neutrophil collagenase and Collagenase 3 inhibitor n-[[2-methy... 1 4
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 13 3
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neprilysin inhibitor SureCN7437961 family 2 6
Pol polyprotein inhibitor AC1L9R8I family 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
Renin inhibitor 2-methylpropyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl... 14 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Pol polyprotein inhibitor AC1LA3C0 family 2 18
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor (2R,3R)... 1 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 13
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Pol polyprotein and Pepsin A inhibitor cgp 53820 family 1 1
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 1
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00231923 DNC003848 Investigative Drug PKF-241-466

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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