CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1211
Family Name Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Ligand L-755507 Family
No. of Seeds 40 No. of Other Members 90
Family Centroid CFAMM00232055 Functional Category Investigative Drug
Superfamily Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Ligand L-755507 Superfamily
Class Class 287

Cousin Family NamesSeedsMembers
Beta-2 adrenergic receptor Ligand Formoterol Family 16 63
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Potassium voltage-gated channel subfamily H member 2 Ligand Do... 5 30
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Beta-3 adrenergic receptor Ligand Cgp 12177 Family 3 8
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Beta-3 adrenergic receptor Ligand BMS-196085 Family 18 72
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Beta-1 adrenergic receptor ligand 4-[2-[[(2S)-3-(2-cyano-5-flu... 3 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 5 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 3
Transient receptor potential cation channel subfamily V member... 3 15
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 16 6
Androgen receptor ligand AGN-PC-00BRQF family 2 2
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 2
Beta-3 adrenergic receptor ligand 2-[(5Z)-5-[[4-[4-[[(2S)-2-hy... 3 2
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 1
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 0
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
Glutamate receptor ionotropic, NMDA 1 ligand N-[4-[(2S)-3-[2-(... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00232031 CHEMBL274144 Bioactive 1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-1-methylurea
CFAMM00231997 CHEMBL13389 Bioactive methyl N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]carbamate
CFAMM00232011 CHEMBL1203991 Bioactive 1-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-(4-sulfamoylphenyl)thiourea;hydrochloride
CFAMM00231938 CHEMBL183211 Bioactive 1-[4-[(2S)-2-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-phenylurea
CFAMM00231957 CHEMBL13459 Bioactive 1-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-3-pentylurea
CFAMM00232017 CHEMBL13398 Bioactive SureCN13959121
CFAMM00232030 CHEMBL274143 Bioactive 3-hexyl-1-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-1-methylurea
CFAMM00232043 CHEMBL182127 Bioactive 1-cyclohexyl-3-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]urea
CFAMM00231937 CHEMBL275291 Bioactive 1-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-3-propan-2-ylurea
CFAMM00231976 CHEMBL12686 Bioactive N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-4-methoxybenzenesulfonamide
CFAMM00232002 CHEMBL12718 Bioactive N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-4-methylbenzenesulfonamide
CFAMM00232049 CHEMBL106022 Bioactive SureCN7094547
CFAMM00231956 CHEMBL12943 Bioactive N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]propanamide
CFAMM00232029 CHEMBL12864 Bioactive 1-hexyl-3-[3-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea
CFAMM00231995 CHEMBL13068 Bioactive N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-2-methylpropanamide
CFAMM00232022 CHEMBL12674 Bioactive SureCN9267356
CFAMM00232001 CHEMBL12911 Bioactive ethyl N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]carbamate
CFAMM00232015 CHEMBL13453 Bioactive N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]butanamide
CFAMM00231935 CHEMBL13106 Bioactive propan-2-yl N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]carbamate
CFAMM00231961 CHEMBL275114 Bioactive 1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-1,3-dimethylurea
CFAMM00232047 CHEMBL434524 Bioactive 1-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-phenylurea
CFAMM00232000 CHEMBL13467 Bioactive 1-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-3-octylurea
CFAMM00232060 CHEMBL268289 Bioactive N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]heptanamide
CFAMM00231941 CHEMBL275511 Bioactive 1-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-3-propylurea
CFAMM00232014 CHEMBL273428 Bioactive N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]acetamide
CFAMM00232040 CHEMBL102194 Bioactive SureCN7139311
CFAMM00232053 CHEMBL13132 Bioactive benzyl N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]carbamate
CFAMM00231940 CHEMBL417250 Bioactive N-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]benzamide
CFAMM00231953 CHEMBL13521 Bioactive 1-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]-3-(3-methoxypropyl)urea
CFAMM00231979 CHEMBL144870 Bioactive 1-heptyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea
CFAMM00232032 CHEMBL563872 Bioactive N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]benzenesulfonamide
CFAMM00232045 CHEMBL56968 Bioactive N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-2,3-dihydro-1H-indole-5-sulfonamide
CFAMM00231939 CHEMBL67886 Bioactive N-[4-[2-[[(2S)-2-hydroxy-3-(4-methoxyphenoxy)propyl]amino]ethyl]phenyl]-4-iodobenzenesulfonamide
CFAMM00231998 CHEMBL1204383 Bioactive 1-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-3-phenylurea;hydrochloride
CFAMM00232058 CHEMBL13432 Bioactive 1-cyclohexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea
CFAMM00232025 CHEMBL431048 Bioactive SureCN7137130
CFAMM00231991 CHEMBL417613 Bioactive SureCN9269408
CFAMM00231932 CHEMBL276257 Bioactive SureCN289708
CFAMM00232018 CHEMBL183129 Bioactive 1-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]-3-phenylurea
CFAMM00232055 DNC003854 Investigative Drug L-755507

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543