CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1214
Family Name Disintegrin and metalloproteinase domain-containing protein 17 and Collagenase 3 Inhibitor PKF-242-484 Family
No. of Seeds 25 No. of Other Members 36
Family Centroid CFAMM00232167 Functional Category Investigative Drug with Natural Product
Superfamily Disintegrin and A disintegrin Binder Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand DA-5018 Family 14 73
Plitidepsin family 15 5
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Vasopeptidase Inhibitor Fasidotril Family 3 7
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Integrin beta-3 Inhibitor FK-633 Family 2 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
Pol polyprotein inhibitor 180968-31-4 family 8 13
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H3 receptor ligand SureCN4319687 family 8 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-carboxyethyl(2-phenoxye... 1 3
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 2 0
Neprilysin inhibitor SureCN389939 family 5 6
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 12
Pol polyprotein inhibitor MDL 74538 family 11 1
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 3 0
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 21e family 6 7
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Macrophage metalloelastase and Collagenase 3 inhibitor N-hydro... 2 3
Macrophage metalloelastase and Collagenase 3 inhibitor (2S)-N-... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 3 5
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Histamine H3 receptor ligand SureCN7244264 family 1 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-4-o... 4 5
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
72 kDa type IV collagenase inhibitor AGN-PC-03EJ2S family 8 5
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 9
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Caspase-1 inhibitor 3-[[(2S)-4-hydroxy-1-[(2S)-3-methyl-2-[[(E... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
C-C chemokine receptor type 2 ligand (E)-N-[(1S,3R)-3-[[4-(4-m... 1 6
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Dipeptidyl peptidase 4 inhibitor 3-[[2-[(2S,4S)-2-cyano-4-fluo... 5 1
Sigma non-opioid intracellular receptor 1 ligand (1R,5S)-9-[(4... 3 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Dipeptidyl peptidase 4 inhibitor 7-[(3R)-3-amino-4-(2,4,5-trif... 2 0
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
Histamine H3 receptor ligand (2S)-N-[(4-methoxyphenyl)methyl]-... 1 7
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN4877195 family 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0
NP N-(2-methoxyphenethyl)-5-((3as,4s,6ar)-2-oxohexahydro-1h-th... 2 0
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00232135 CHEMBL66134 Bioactive (3S,6R,7S)-7-N-hydroxy-6-(2-methylpropyl)-3-N-(2-methylsulfanylethyl)-5-oxo-12-oxa-4-azabicyclo[11.2.2]heptadeca-1(15),13,16-triene-3,7-dicarboxamide
CFAMM00232145 CHEMBL418292 Bioactive (3S,6R,7S)-7-N-hydroxy-3-N-methyl-6-(2-methylpropyl)-5-oxo-12-oxa-4-azabicyclo[11.2.2]heptadeca-1(15),13,16-triene-3,7-dicarboxamide
CFAMM00232160 CHEMBL95881 Bioactive tert-butyl (3S,6R,7R)-3-[[6-(hydroxyamino)-6-oxohexyl]carbamoyl]-6-(2-methylpropyl)-13-oxa-4-azabicyclo[12.2.2]octadeca-1(16),14,17-triene-7-carboxylate
CFAMM00232139 CHEMBL62007 Bioactive (3S,6R,7S)-7-N-hydroxy-3-N-methyl-6-(2-methylpropyl)-5-oxo-13-oxa-4-azabicyclo[12.2.2]octadeca-1(16),14,17-triene-3,7-dicarboxamide
CFAMM00232169 CHEMBL168802 Bioactive (2R,3R)-N,2-dihydroxy-N'-[(2S)-3-(4-methoxyphenyl)-1-(methylamino)-1-oxopropan-2-yl]-2-methyl-3-(3-phenylpropyl)butanediamide
CFAMM00232147 CHEMBL315493 Bioactive (2R)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(4-phenoxybutyl)butanediamide
CFAMM00232176 CHEMBL45631 Bioactive (3S,6R,7S)-7-N-hydroxy-3-N-methyl-6-(2-methylpropyl)-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(14),12,15-triene-3,7-dicarboxamide
CFAMM00232167 DNC003860 Investigative Drug PKF-242-484

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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