CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1216
Family Name 5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydroquinazolin-2-amine Family
No. of Seeds 8 No. of Other Members 51
Family Centroid CFAMM00232366 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 5A Binder Superfamily
Class Class 2027

Cousin Family NamesSeedsMembers
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor Ligand Epinastine Family 2 26
Histamine H1 receptor Ligand Antazoline Family 5 57
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 18
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 3 2
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 8
Nitric oxide synthase, brain inhibitor N'-[3-(aminomethyl)phen... 2 6
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 1 2
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 2 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
5-hydroxytryptamine receptor 5A ligand N-(1,4-dioxan-2-ylmethy... 1 1
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 1
Beta-lactamase and Prelamin-A/C inhibitor CHEMBL1560571 family 1 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 1
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0
Dihydrofolate reductase inhibitor 5-[[4-(dimethylamino)phenyl]... 1 0
Sodium channel protein type 2 subunit alpha and Glutamate rece... 1 0
Polyamine oxidase inhibitor AGN-PC-07C3XH family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00232342 DNC008146 Investigative Drug N,N-dimethyl-3,4-dihydroquinazolin-2-amine
CFAMM00232335 DNC003866 Investigative Drug Imidazolidin-2-ylidene-o-tolyl-amine
CFAMM00232366 DNC008171 Investigative Drug N,4-dimethyl-3,4-dihydroquinazolin-2-amine
CFAMM00232341 DNC008147 Investigative Drug 4-propyl-3,4-dihydroquinazolin-2-amine
CFAMM00232356 DNC008169 Investigative Drug N-butyl-4-methyl-3,4-dihydroquinazolin-2-amine
CFAMM00232339 DNC008148 Investigative Drug 4-ethyl-3,4-dihydroquinazolin-2-amine
CFAMM00232338 DNC008149 Investigative Drug 3,4-dihydroquinazolin-2-amine hydrobromide
CFAMM00232376 DNC008170 Investigative Drug 4-methyl-N-propyl-3,4-dihydroquinazolin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27266 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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