CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1220
Family Name Integrin beta-3 Inhibitor Elarofiban Family
No. of Seeds 28 No. of Other Members 45
Family Centroid CFAMM00232625 Functional Category Investigative Drug with Natural Product
Superfamily Integrin beta-3 Inhibitor Elarofiban Superfamily
Class Class 134

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
HIV-1 protease Inhibitor Atazanavir Family 16 58
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Substance-P receptor Ligand GSK424887 Family 8 184
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
CP-18770 family 6 27
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cathepsin K and Cathepsin S Inhibitor P2,p3 Ketoamide Derivati... 2 1
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03RR5Q f... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(3,5... 28 18
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Endothelin-converting enzyme 1 inhibitor 2-[[1-[[(2S)-4-methyl... 2 8
Coagulation factor X inhibitor (2S)-(3'-AMIDINO-3-BIPHENYL)-5-... 1 0
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Glucocorticoid receptor ligand SureCN3283777 family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Cholecystokinin receptor type A ligand A-65186 family 2 6
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Integrin alpha-4 inhibitor AC1O7HJM family 3 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-3 and Integrin alpha-IIb inhibitor 3-[[1-(3-pipe... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 3 14
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-075FXA f... 1 0
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2833591 f... 4 6
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Prothrombin inhibitor 1o0d family 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(butyl... 2 4
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Integrin beta-3 and Integrin alpha-IIb inhibitor 3-oxo-3-[4-(2... 1 21
Pol polyprotein inhibitor 183854-15-1 family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[3-(2... 4 2
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-(5-chl... 1 0
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1S)-1-carboxy... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBJ4 family 1 0
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-[[2-[3... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00232602 CHEMBL357547 Bioactive 3-(5-bromopyridin-3-yl)-3-[[1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232616 CHEMBL415537 Bioactive (3S)-3-[5-(2-phenylethynyl)pyridin-3-yl]-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232608 CHEMBL58675 Bioactive (3S)-3-[[2-[cyclopropyl-(3-piperidin-4-ylbenzoyl)amino]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232562 CHEMBL358897 Bioactive (3S)-3-(6-chloropyridin-3-yl)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232588 CHEMBL151163 Bioactive (3S)-3-[[(2R)-4-(3-piperidin-4-ylpropanoyl)piperazine-2-carbonyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232628 CHEMBL358779 Bioactive (3S)-3-(6-methylpyridin-3-yl)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232594 CHEMBL87728 Bioactive Elarofiban
CFAMM00232607 CHEMBL358198 Bioactive (3S)-3-(5-ethynylpyridin-3-yl)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232561 CHEMBL58328 Bioactive (3S)-3-[[2-(1-oxo-7-piperazin-1-yl-3,4-dihydroisoquinolin-2-yl)acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232574 CHEMBL356751 Bioactive 3-[5-(3-aminophenyl)pyridin-3-yl]-3-[[1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232587 CHEMBL345276 Bioactive 2-cyclohexylethyl (3S)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoate
CFAMM00232600 CHEMBL150533 Bioactive (3R)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232567 CHEMBL147239 Bioactive (3S)-3-[[(3R)-1-[(E)-3-piperidin-4-ylprop-2-enoyl]pyrrolidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232613 CHEMBL57881 Bioactive (3S)-3-[[2-[(3R)-2-oxo-3-(2-piperidin-4-ylethyl)piperidin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232627 CHEMBL147249 Bioactive 3-(5-phenylpyridin-3-yl)-3-[[1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232560 CHEMBL151314 Bioactive (3R)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]-3-quinolin-3-ylpropanoic acid
CFAMM00232599 CHEMBL149281 Bioactive methyl (3S)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoate
CFAMM00232612 CHEMBL345755 Bioactive (3S)-3-[[(3R)-1-[3-(1-methanimidoylpiperidin-4-yl)propanoyl]piperidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232619 CHEMBL151213 Bioactive (3S)-3-[[(3R)-1-[(E)-3-piperidin-4-ylprop-2-enoyl]piperidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232632 CHEMBL346632 Bioactive (3S)-3-(5-phenylpyridin-3-yl)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232585 CHEMBL293588 Bioactive (3S)-3-[[2-[(3R)-2-oxo-1-(2-piperidin-4-ylethyl)piperidin-3-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232598 CHEMBL148981 Bioactive (3S)-3-(5,6-dichloropyridin-3-yl)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232578 CHEMBL357593 Bioactive (3S)-3-[[(3R)-1-(1-piperidin-4-ylpiperidine-4-carbonyl)piperidine-3-carbonyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00232571 CHEMBL356222 Bioactive (3S)-3-(5-bromopyridin-3-yl)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232597 CHEMBL359111 Bioactive (3S)-3-[5-(2-phenylethyl)pyridin-3-yl]-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]propanoic acid
CFAMM00232624 CHEMBL80623 Bioactive (3S)-3-[[(3R)-1-(3-piperidin-4-ylpropanoyl)piperidine-3-carbonyl]amino]-3-quinolin-3-ylpropanoic acid
CFAMM00232564 CHEMBL149000 Bioactive AGN-PC-075RNN
CFAMM00232625 DNC003876 Investigative Drug ELAROFIBAN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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