CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1222
Family Name Platelet-derived growth factor receptor beta and Epidermal growth factor receptor Ligand 4-(3-bromo-phenoxy)-6,7-dimethoxy-quinoline Family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00232684 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Platelet-derived growth factor receptor beta and Epidermal growth factor receptor Ligand 4-(3-bromo-phenoxy)-6,7-dimethoxy-quinoline Superfamily
Class Class 2031

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Tivozanib family 4 6
Apricoxib family 8 77
8-aminoquinoline Inhibitor Tafenoquine Family 1 0
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bloom syndrome protein and Prelamin-A/C inhibitor Dubinidine f... 1 17
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Transient receptor potential cation channel subfamily V member... 3 2
Small conductance calcium-activated potassium channel protein ... 2 2
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Protein kinase C theta type inhibitor AGN-PC-04SQV8 family 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00232688 CHEMBL462169 Bioactive AGN-PC-078VXT
CFAMM00232684 DNC003884 Investigative Drug 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00232689 DNC011944 Investigative Drug 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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