CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1225
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit alpha-2 Ligand CGS-17867A Family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00232723 Functional Category Investigative Drug
Superfamily D(4) dopamine receptor and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 1532

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00232721 DNC011975 Investigative Drug CGS-8216
CFAMM00232723 DNC003896 Investigative Drug CGS-17867A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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