CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1233
Family Name Potassium voltage-gated channel subfamily H member 2 Ligand 4-benzenesulfonyl-1-phenethyl-piperidine Family
No. of Seeds 4 No. of Other Members 26
Family Centroid CFAMM00232878 Functional Category Investigative Drug
Superfamily Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methylsulfate Superfamily
Class Class 578

Cousin Family NamesSeedsMembers
Muscarinic acetylcholine receptor M5 Ligand Metixene Family 5 24
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 2 39
5-hydroxytryptamine receptor 7 and D(2) dopamine receptor Liga... 3 29
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 12 20
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 4
Alpha-2A adrenergic receptor Ligand SK&F-29661 Family 3 42
Melanin-concentrating hormone receptor 1 Ligand N,n-bis(tosylm... 2 1
D(2) dopamine receptor Ligand 4-[3-(methylsulfonyl)phenyl]-1-p... 2 2
Oxytocin receptor and Vasopressin V1a receptor Ligand 1'-tosyl... 1 7
5-hydroxytryptamine receptor 1A Ligand 2-(biphenyl-3-ylthio)-n... 1 3
Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 34
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 11
Histamine H3 receptor ligand 2-[4-[4-[2-[(2R)-2-methylpyrrolid... 4 11
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 6 4
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 4 12
Histamine H3 receptor and Potassium voltage-gated channel subf... 14 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 10
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-4-[(... 3 2
Sigma non-opioid intracellular receptor 1 ligand 4-benzyl-1-[(... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Ileal sodium/bile acid cotransporter inhibitor (3R,5R)-3-butyl... 1 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0


External ID

Functional Category

Molecule Name

CFAMM00232892 CHEMBL204171 Bioactive SureCN6097629
CFAMM00232894 DNC003915 Investigative Drug 4-Benzenesulfonyl-1-(3-phenyl-propyl)-piperidine
CFAMM00232878 DNC003920 Investigative Drug 4-Benzenesulfonyl-1-phenethyl-piperidine
CFAMM00232907 DNC010447 Investigative Drug 1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperidine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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