CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1238
Family Name Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen-(2s,3r)-2-me-(2')nal-gsfc]kr-nh2 Family
No. of Seeds 20 No. of Other Members 66
Family Centroid CFAMM00233040 Functional Category Investigative Drug
Superfamily Nociceptin receptor and Mu-type opioid receptor Binder Superfamily
Class Class 2037

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Plitidepsin family 15 5
Tryptase Inhibitor APC-366 Family 2 12
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Somatostatin receptor type 1 Ligand Des-aa1,2,5-[(nalphame)lys... 16 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor AC1LADQG family 7 1
C-X-C chemokine receptor type 4 ligand CHEMBL2012526 family 4 8
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 3 16
Oxytocin receptor ligand (2S)-N-[(2R)-1-[2-[[5-amino-1-[[1-ami... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
Somatostatin receptor type 2 ligand CHEMBL526524 family 3 0
Somatostatin receptor type 2 and Somatostatin receptor type 3 ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
IgG receptor FcRn large subunit p51 ligand (4S,7S,16S,22S,25R,... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00233012 CHEMBL558161 Bioactive (4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-7,16-dibenzyl-13-[methyl(naphthalene-2-carbonyl)amino]-6,9,12,15,18-pentaoxo-10-[[4-[(propan-2-ylamino)methyl]phenyl]methyl]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
CFAMM00233011 CHEMBL2369475 Bioactive (4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-13-(3-aminopropyl)-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-3,3-dimethyl-6,9,12,15,18-pentaoxo-19-[[(3S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
CFAMM00233009 CHEMBL2372983 Bioactive CHEMBL2372983
CFAMM00232989 CHEMBL415359 Bioactive (4R,7S,10R,13S,16R,19S,22R,25S)-13-(4-aminobutyl)-25-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-19-[(4-aminophenyl)methyl]-7,22-dibenzyl-10-[(1R)-1-hydroxyethyl]-16-[(1S)-1-naphthalen-2-ylethyl]-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carboxylic acid
CFAMM00233001 CHEMBL2370137 Bioactive CHEMBL2370137
CFAMM00233007 CHEMBL2373002 Bioactive CHEMBL2373002
CFAMM00233020 CHEMBL2372996 Bioactive CHEMBL2372996
CFAMM00232999 DNC003961 Investigative Drug Y-c[D-Pen-(2R,3S)-2-Me-(2')Nal-GSFC]KR-NH2
CFAMM00233015 DNC003952 Investigative Drug Y-c[D-Pen-(2S,3S)-2-Me-(2')Nal-GSFC]KR-NH2
CFAMM00233040 DNC003923 Investigative Drug Y-c[D-Pen-(2S,3R)-2-Me-(2')Nal-GSFC]KR-NH2
CFAMM00232974 DNC004747 Investigative Drug Des-AA1,2,5-[D-Nal8,(NalphaMe)IAmp9,Tyr11]SRIF
CFAMM00233039 DNC003927 Investigative Drug Y-c[D-Pen-(2R,3R)-2-Me-(2')Nal-GSFC]KR-NH2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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