CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1247
Family Name Integrin beta-3 Inhibitor L-709780 Family
No. of Seeds 9 No. of Other Members 10
Family Centroid CFAMM00233219 Functional Category Investigative Drug
Superfamily Integrin beta-3 Inhibitor L-709780 Superfamily
Class Class 486

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor Sibrafiban Family 4 6
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 11
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-b... 3 4
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 2 8
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 7 18
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 3 0
Caspase-1 and Caspase-8 inhibitor benzyl (4S,7S,9Z,11aS)-7-ben... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-... 4 4
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074AY6... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
Caspase-1 inhibitor (3S)-3-[[(4S,7S)-7-[(2-fluorobenzoyl)amino... 4 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-[... 8 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(2-eth... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-3-[[3-ox... 2 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-4-N... 1 1
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Breast cancer type 1 susceptibility protein inhibitor (2S)-2-[... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00233223 CHEMBL441438 Bioactive (3S)-4-hydroxy-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]butanoic acid
CFAMM00233222 CHEMBL315065 Bioactive (2S)-2-(butylsulfonylamino)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]propanoic acid
CFAMM00233206 CHEMBL83015 Bioactive (2S)-2-(benzylcarbamoylamino)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]propanoic acid
CFAMM00233221 CHEMBL82862 Bioactive (2S)-2-(methanesulfonamido)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]propanoic acid
CFAMM00233213 CHEMBL310294 Bioactive (2S)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]-2-(pentylsulfonylamino)propanoic acid
CFAMM00233212 CHEMBL311734 Bioactive (2S)-2-(2-methylpropylsulfonylamino)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]propanoic acid
CFAMM00233211 CHEMBL84774 Bioactive (2S)-2-(butylcarbamoylamino)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]propanoic acid
CFAMM00233218 CHEMBL309742 Bioactive (2S)-2-(hexanoylamino)-3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1H-isoindole-5-carbonyl]amino]propanoic acid
CFAMM00233219 DNC003955 Investigative Drug L-709780

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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