CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1254
Family Name Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ionotropic, NMDA 2B Ligand N,n'-bis-(4-butyl-phenyl)-guanidine Family
No. of Seeds 14 No. of Other Members 78
Family Centroid CFAMM00233529 Functional Category Investigative Drug with Natural Product
Superfamily Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ionotropic, NMDA 2B Ligand N,n'-bis-(4-butyl-phenyl)-guanidine Superfamily
Class Class 655

Cousin Family NamesSeedsMembers
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Peptide deformylase, mitochondrial Inhibitor Proguanil Family 8 46
Histamine H1 receptor Ligand Epinastine Family 2 26
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
NMDA receptor Ligand CNS-5161 Family 3 18
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Transient receptor potential cation channel subfamily V member... 6 33
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Androgen receptor Ligand YM-175735 Family 30 129
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 18
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Tyrosinase Inhibitor Phenylthiourea Family 1 6
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Voltage-dependent L-type calcium channel subunit alpha-1D Liga... 1 11
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Prelamin-A/C and Bloom syndrome protein inhibitor Xylazine hyd... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(2-adamantyl)-3-(... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 5 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 9
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 3 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 1 10
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 1 5
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 8
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 1
Nitric oxide synthase, brain inhibitor N'-[3-(aminomethyl)phen... 2 6
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 1 2
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 2 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 3
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 1
Nitric oxide synthase, brain inhibitor SureCN7780818 family 2 0
Beta-lactamase and Prelamin-A/C inhibitor CHEMBL1560571 family 1 5
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0
Dihydrofolate reductase inhibitor 5-[[4-(dimethylamino)phenyl]... 1 0
Sodium channel protein type 2 subunit alpha and Glutamate rece... 1 0
Polyamine oxidase inhibitor AGN-PC-07C3XH family 1 2
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00233559 CHEMBL176987 Bioactive 6,6-dimethyl-1-(4-octylphenyl)-1,3,5-triazine-2,4-diamine
CFAMM00233551 CHEMBL552829 Bioactive AGN-PC-07C07L
CFAMM00233566 CHEMBL7004 Bioactive GNF-Pf-4555
CFAMM00233565 CHEMBL174559 Bioactive 1-(4-heptylphenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
CFAMM00233468 CHEMBL172558 Bioactive 1-(4-hexylphenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
CFAMM00233521 CHEMBL91345 Bioactive AC1MDQO2
CFAMM00233541 DNC011515 Investigative Drug N,N'-Bis-(4-ethyl-phenyl)-guanidine
CFAMM00233502 DNC011524 Investigative Drug N,N'-Bis-(4-hexyl-phenyl)-guanidine
CFAMM00233486 DNC003974 Investigative Drug DITOLYLGUANIDINE
CFAMM00233530 DNC011509 Investigative Drug N,N'-Bis-(4-isopropyl-phenyl)-guanidine
CFAMM00233500 DNC011528 Investigative Drug N,N'-Bis-(4-sec-butyl-phenyl)-guanidine
CFAMM00233529 DNC011505 Investigative Drug N,N'-Bis-(4-butyl-phenyl)-guanidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27512 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543