CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1255
Family Name 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-phenyl)-1-methyl-piperidin-2-one Family
No. of Seeds 10 No. of Other Members 52
Family Centroid CFAMM00233581 Functional Category Investigative Drug
Superfamily 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-phenyl)-1-methyl-piperidin-2-one Superfamily
Class Class 2042

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Opioid receptor Ligand Methadone Family 3 39
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 2 9
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Scytalone dehydratase Inhibitor Carpropamid Family 5 2
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor Bexlosteride... 5 23
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Sodium-dependent dopamine transporter and Transporter inhibito... 4 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Substance-K receptor ligand SureCN3083325 family 4 0
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 5 ligand AGN-PC-075XOD family 2 0
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 11 2
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[(4S)-4-(4-chlo... 15 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Mu-type opioid receptor ligand CHEMBL303404 family 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Prolyl endopeptidase inhibitor [(2S)-2-(pyrrolidine-1-carbonyl... 3 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 3
Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... 1 3
Dipeptidyl peptidase 4 inhibitor SureCN14523901 family 7 1
Retinal dehydrogenase 1 and Muscleblind-like protein 1 inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00233577 CHEMBL340138 Bioactive AGN-PC-03WECT
CFAMM00233592 CHEMBL338220 Bioactive AGN-PC-03WEEN
CFAMM00233598 CHEMBL340317 Bioactive AGN-PC-03WECX
CFAMM00233616 CHEMBL52324 Bioactive (1R,3S)-3-(4-chlorophenyl)-N,N,8-trimethyl-8-azabicyclo[3.2.1]octane-4-carboxamide
CFAMM00233630 CHEMBL126229 Bioactive AGN-PC-03WED6
CFAMM00233588 CHEMBL562614 Bioactive AGN-PC-071J6Q
CFAMM00233607 CHEMBL126682 Bioactive AGN-PC-03WED5
CFAMM00233593 CHEMBL51355 Bioactive SureCN14173869
CFAMM00233585 CHEMBL128766 Bioactive SureCN10347265
CFAMM00233581 DNC003979 Investigative Drug 5-(4-Chloro-phenyl)-1-methyl-piperidin-2-one

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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