CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID126
Family Name Platelet activating factor, putative Inhibitor ABT-491 Family
No. of Seeds 22 No. of Other Members 62
Family Centroid CFAMM00181826 Functional Category Investigative Drug
Superfamily Platelet activating factor, putative Inhibitor ABT-491 Superfamily
Class Class 1418

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
NS5A protein Inhibitor Bms 790052 Family 5 9
IPI-145 family 2 4
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
Smoothened homolog Inhibitor LY2940680 Family 3 18
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Class II cytokine receptor Ligand IL-10 Family 7 45
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Serine/threonine-protein kinase Chk1 Inhibitor Granulatimide F... 1 1
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Gamma-aminobutyric acid receptor Ligand BRL-54504AX Family 1 2
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Platelet-activating factor receptor ligand A-85783 family 13 62
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Smoothened homolog inhibitor SureCN1091571 family 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cannabinoid receptor 2 ligand AGN-PC-080WIY family 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Tyrosine-protein kinase ABL1 inhibitor 5-[(5-{[4-{[4-(2-Hydrox... 4 1
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 4 4
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Prelamin-A/C and Niemann-Pick C1 protein inhibitor CHEMBL13592... 1 16
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 7
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 6 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Histamine H3 receptor ligand SureCN2878688 family 8 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Rho-associated protein kinase 2 and Rho-associated protein kin... 4 9
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Cholecystokinin receptor type A ligand 6-[2-[2-(cyclohexylmeth... 2 6
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Renin inhibitor AGN-PC-073MLF family 7 6
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 3 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Glycogen synthase kinase-3 beta inhibitor 3-(5-bromo-1-methyli... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 6 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
C-X-C chemokine receptor type 3 ligand AGN-PC-07CQOB family 17 10
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Glycogen synthase kinase-3 beta inhibitor GSK-3beta Inhibitor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[[3-(2-aminoet... 8 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Platelet-activating factor receptor ligand SureCN7494441 family 1 1
Platelet-activating factor receptor ligand SureCN7497807 family 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Melanocortin receptor 3 and Melanocyte-stimulating hormone rec... 2 3
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04SU6B family 2 3
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 3 7
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935256 family 1 0
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
Fatty acid synthase inhibitor 4-[1-[2,4-dimethyl-5-(6-methylsu... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00181880 CHEMBL433795 Bioactive 200418-08-2
CFAMM00181873 CHEMBL1172397 Bioactive AGN-PC-04S3QT
CFAMM00181886 CHEMBL366553 Bioactive 4-ethyl-N,N-dimethyl-3-[4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-1-carboxamide
CFAMM00181839 CHEMBL176797 Bioactive SureCN7498857
CFAMM00181879 CHEMBL172484 Bioactive SureCN7848279
CFAMM00181845 CHEMBL172697 Bioactive SureCN7497167
CFAMM00181859 CHEMBL367418 Bioactive AGN-PC-00GEZ2
CFAMM00181825 CHEMBL173584 Bioactive SureCN7494866
CFAMM00181831 CHEMBL174859 Bioactive (4-ethynyl-1H-indol-3-yl)-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]phenyl]methanone
CFAMM00181844 CHEMBL173642 Bioactive SureCN7847829
CFAMM00181824 CHEMBL174550 Bioactive SureCN7836316
CFAMM00181884 CHEMBL1172585 Bioactive SureCN589960
CFAMM00181851 CHEMBL174402 Bioactive 4-benzamido-N,N-dimethyl-3-[4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-1-carboxamide
CFAMM00181816 CHEMBL367398 Bioactive SureCN7494020
CFAMM00181830 CHEMBL367295 Bioactive SureCN7497571
CFAMM00181857 CHEMBL427121 Bioactive SureCN9053469
CFAMM00181823 CHEMBL173191 Bioactive 4-(4-fluorophenyl)-N,N-dimethyl-3-[4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-1-carboxamide
CFAMM00181807 CHEMBL367964 Bioactive SureCN7497936
CFAMM00181888 CHEMBL176725 Bioactive SureCN7496311
CFAMM00181855 CHEMBL369225 Bioactive 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide
CFAMM00181820 CHEMBL173122 Bioactive 4-ethynyl-N,N-dimethyl-3-[4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-1-carboxamide
CFAMM00181826 DNC000131 Investigative Drug ABT-491

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26388 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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