CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1268
Family Name Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family
No. of Seeds 27 No. of Other Members 36
Family Centroid CFAMM00233889 Functional Category Investigative Drug with Natural Product
Superfamily BIBT986 Superfamily
Class Class 716

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Epidermal Growth Factor family 111 209
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
CC-486 family 7 103
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Pol polyprotein inhibitor AC1LAQE0 family 13 4
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[[4-[2-(... 3 3
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Integrin alpha-4 inhibitor AC1O7HJM family 3 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Thymidylate synthase inhibitor AGN-PC-0757PM family 1 0
Endothelin-1 receptor and Endothelin B receptor ligand SureCN9... 3 10
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[[(1R,4S... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-(benzene... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino... 5 6
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Type-1 angiotensin II receptor ligand 7-methyl-N-(2-phenylethy... 2 10
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 2
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 2 8
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[(5S,11S,14... 2 2
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor (2S)-2... 2 4
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 1 7
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-fluorop... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00233906 CHEMBL419374 Bioactive 2-[(2S)-4-(3,3-dimethylbutyl)-7-[1H-imidazo[4,5-b]pyridin-2-ylmethyl(methyl)carbamoyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233886 CHEMBL106763 Bioactive SureCN7074284
CFAMM00233899 CHEMBL418999 Bioactive SureCN6944353
CFAMM00233912 CHEMBL107927 Bioactive 2-[(2S)-7-[1H-imidazo[4,5-b]pyridin-2-ylmethyl(methyl)carbamoyl]-4-methyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233879 CHEMBL109003 Bioactive SureCN7074204
CFAMM00233892 CHEMBL325548 Bioactive 2-[(2S)-7-(1H-benzimidazol-2-ylmethylcarbamoyl)-3-oxo-4-(2-phenylethyl)-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233905 CHEMBL108490 Bioactive 2-[(2S)-7-[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]-4-(3,3-dimethylbutyl)-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233871 CHEMBL106456 Bioactive SureCN8323490
CFAMM00233898 CHEMBL298782 Bioactive 2-[(2S)-7-[2-[(6-aminopyridin-2-yl)amino]ethylcarbamoyl]-4-methyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233911 CHEMBL110520 Bioactive 2-[(2S)-7-[1H-imidazo[4,5-b]pyridin-2-ylmethyl(methyl)carbamoyl]-3-oxo-4-propan-2-yl-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233851 CHEMBL108685 Bioactive SureCN8328583
CFAMM00233904 CHEMBL110517 Bioactive SureCN8325096
CFAMM00233897 CHEMBL327089 Bioactive SureCN8467042
CFAMM00233868 CHEMBL299591 Bioactive SureCN7788816
CFAMM00233882 CHEMBL322416 Bioactive 2-[(2S)-7-[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]-4-(2-methoxyethyl)-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233861 CHEMBL321648 Bioactive 2-[(2S)-7-[1H-imidazo[4,5-b]pyridin-2-ylmethyl(methyl)carbamoyl]-4-(2-methoxyethyl)-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233914 CHEMBL106036 Bioactive 2-[(2S)-7-[1H-benzimidazol-2-ylmethyl(cyanomethyl)carbamoyl]-4-methyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233854 CHEMBL110413 Bioactive SureCN8329426
CFAMM00233867 CHEMBL418818 Bioactive 2-[(2S)-4-methyl-7-[methyl-[(5-methyl-1H-imidazo[4,5-b]pyridin-2-yl)methyl]carbamoyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233881 CHEMBL420666 Bioactive SureCN7077079
CFAMM00233894 CHEMBL54138 Bioactive 2-[(2S)-7-[2-(1H-imidazol-2-ylamino)ethylcarbamoyl]-4-methyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233907 CHEMBL419376 Bioactive SureCN7916989
CFAMM00233887 CHEMBL52026 Bioactive 2-[(2S)-7-[(2-amino-1H-imidazol-5-yl)methylcarbamoyl]-4-methyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233853 CHEMBL110412 Bioactive SureCN8468929
CFAMM00233880 CHEMBL419180 Bioactive 2-[(2S)-7-[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]-4-benzyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00233893 CHEMBL105982 Bioactive SureCN7909948
CFAMM00233889 DNC004015 Investigative Drug SB-223245

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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