CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1274
Family Name Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-val-ome Family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00233980 Functional Category Investigative Drug
Superfamily Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-val-ome Superfamily
Class Class 414

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin receptor Ligand Insulin, Porcine Family 61 205
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Renin Inhibitor Enalkiren Family 56 44
Caspase-9 Inhibitor Z-lehd-fmk Family 1 0
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Glycylpeptide N-tetradecanoyltransferase Inhibitor SC-58272 Fa... 2 11
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein and Protease inhibitor 161186-52-3 family 3 3
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Pol polyprotein inhibitor AC1LA3L0 family 3 2
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 7
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Placenta growth factor inhibitor CHEMBL1689479 family 4 1
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-(3-imidazo... 1 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Neuropeptide Y receptor type 2 ligand CHEMBL411765 family 1 0
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-4-[4-[3-(1... 2 1
Epidermal growth factor receptor ligand CHEMBL437469 family 1 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Growth hormone secretagogue receptor type 1 ligand CHEMBL52599... 1 0
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16g... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00233982 CHEMBL429171 Bioactive (2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxy-3-phenylpropanoic acid
CFAMM00233979 CHEMBL2028921 Bioactive methyl (2S)-2-[[(2S,3S)-2-[[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-4-methyl-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoyl]amino]propanoyl]amino]carbamoylamino]-3-methylpentanoyl]amino]-3-methylbutanoate
CFAMM00233980 DNC004027 Investigative Drug Z-Ala-Leu-His-Agly-Ile-Val-OMe

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27029 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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