CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1276
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-bis-(3-cyclopentyloxy-4-methoxy-phenyl)-furan Family
No. of Seeds 2 No. of Other Members 96
Family Centroid CFAMM00234051 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase 2 and cAMP-specific 3',5'-cyclic phosphodiesterase 4A Binder Superfamily
Class Class 543

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Muscarinic acetylcholine receptor Ligand Mebeverine Family 2 27
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 102
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Amine oxidase [flavin-containing] B inhibitor 5-(4,4,4-trifluo... 2 9
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1-benzofuran-5-yl)... 4 2
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Thromboxane A2 receptor and Prostacyclin receptor ligand AGN-P... 2 30
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 8
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Acetylcholinesterase and Butyrylcholinesterase inhibitor 2-[4-... 3 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Putative fructose-1,6-bisphosphate aldolase and Retinal dehydr... 1 0
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Prothrombin inhibitor sodium;[3-ethoxycarbonyl-2-[[3-ethoxycar... 1 6
Arachidonate 5-lipoxygenase inhibitor 5-(1,3-benzodioxol-5-yl)... 2 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Fyn in... 1 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor (2Z)-... 2 10
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Prenol Lipids Metabolite Rosmadial Family 1 0
Naphthofurans Metabolite Pyrocurzerenone Family 1 9
NP (z)-2-(2,3-dimethoxybenzylidene)-3-oxo-2,3-dihydrobenzofura... 9 0
2-benzoyl-3-(3,4-dimethoxyphenyl)-2-ethylcyclopropane-1,1-dica... 4 0
1,3-dimethylcyclohepta[c]furan-8-one NP 6-(4-hydroxy-3-iodo-5-... 13 1
NP 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-ethyl-4-oxo-4h-ch... 33 4
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-6-ethyl-4... 10 0
Putative NP ZINC04025923 Family 6 0
NP (z)-6-((4-bromobenzyl)oxy)-2-(3,4-dimethoxybenzylidene)benz... 13 2
(E)-3-(3,4-dimethoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one NP (... 1 0
NP 4-(7-methoxybenzofuran-2-yl)-2-oxo-7-phenyl-2h-chromen-6-yl... 9 0
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-2-methyl-... 2 0
benzenesulfonate NP (z)-3-oxo-2-(3,4,5-trimethoxybenzylidene)-... 26 0
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
NP Ethyl 7-((2-chlorobenzoyl)oxy)-3-(2-methoxyphenyl)-4-oxo-4h... 37 1
NP 4-(3,4-dimethoxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)but... 2 3
bromobenzoate NP ZINC09346025 Family 20 0
NP Af-399/42316321 Family 7 0
benzenesulfonate NP ZINC09708075 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00234051 DNC004032 Investigative Drug 2,5-Bis-(3-cyclopentyloxy-4-methoxy-phenyl)-furan
CFAMM00234098 DNC004060 Investigative Drug 2,5-Bis-(3,4-dimethoxy-phenyl)-furan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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