CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1291
Family Name Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand 7-methoxy-3-pyridin-4-yl-quinoline Family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00234494 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 and Platelet-derived growth factor receptor beta Binder Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Apricoxib family 8 77
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Tyrosine kinase Inhibitor PKI166 Family 17 198
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
D(2) dopamine receptor ligand 129722-25-4 family 2 2
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 4
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Epidermal growth factor receptor and Proto-oncogene tyrosine-p... 1 0
Renin inhibitor SureCN6043852 family 2 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
Metabotropic glutamate receptor 1 ligand (Z)-[(3-ethyl-2-metho... 1 4
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00234488 DNC004100 Investigative Drug 5,7-Dimethoxy-3-pyridin-4-yl-quinoline
CFAMM00234494 DNC004068 Investigative Drug 7-Methoxy-3-pyridin-4-yl-quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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