CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID1292
Family Name Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-methoxy-5-oxazol-5-yl-1h-indole Family
No. of Seeds 9 No. of Other Members 80
Family Centroid CFAMM00234553 Functional Category Investigative Drug with Natural Product
Superfamily Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 140
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Fatty-acid amide hydrolase 1 inhibitor SureCN1471727 family 2 19
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Inosine-5'-monophosphate dehydrogenase 2 inhibitor 7-methoxy-2... 7 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Neprilysin and Natriuretic peptides A inhibitor (2S)-2-[[1-[[(... 3 3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN72661... 3 3
Inosine-5'-monophosphate dehydrogenase 2 inhibitor 7-methoxy-6... 7 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AC1LAY14 fa... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00234531 CHEMBL38738 Bioactive N,N-dimethyl-2-[5-(5-methyl-1,3-oxazol-2-yl)-1H-indol-3-yl]ethanamine
CFAMM00234524 CHEMBL358876 Bioactive 2-(3,4-dimethylphenyl)-7-methoxy-6-(1,3-oxazol-5-yl)-1H-quinolin-4-one
CFAMM00234595 CHEMBL152959 Bioactive SureCN6484801
CFAMM00234522 CHEMBL152988 Bioactive SureCN6482936
CFAMM00234505 CHEMBL356236 Bioactive SureCN6490362
CFAMM00234591 CHEMBL150777 Bioactive SureCN5012473
CFAMM00234555 CHEMBL23843 Bioactive SureCN6493340
CFAMM00234519 DNC004070 Investigative Drug 6-Methoxy-5-oxazol-5-yl-2-phenyl-1H-indole
CFAMM00234553 DNC004069 Investigative Drug 2-Benzyl-6-methoxy-5-oxazol-5-yl-1H-indole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27520 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543